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Literature summary extracted from

  • Daniel, D.; Middleton, R.; Henry, H.L.; Okamura, W.H.
    Inhibitors of 25-hydroxyvitamin D3 1a-hydroxylase: A-ring oxa analogs of 25-hydroxyvitamin D3 (1996), J. Org. Chem., 61, 5617-5625.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.15.18 malate
-
 Gallus gallus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.15.18 25-hydroxy-3-deoxy-2-oxavitamin D3 vitamin D3 analogue, competitive inhibition Gallus gallus
1.14.15.18 3-deoxy-2-oxa-9(11)-didehydro-25-hydroxyvitamin D3 vitamin D3 analogue, competitive inhibition Gallus gallus
1.14.15.18 A-homo-3-deoxy-2-oxa-25-hydroxyvitamin D3 vitamin D3 analogue, competitive inhibition Gallus gallus
1.14.15.18 additional information overview, inhibitory potency of several vitamin D3 analogues Gallus gallus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.15.18 mitochondrion
-
 Gallus gallus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.18 Gallus gallus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.14.15.18 calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitriol + 2 oxidized adrenodoxin + H2O 25-hydroxyvitamin D3 1alpha-hydroxylase is a cytochrome P-450-dependent mixed-function oxidase Gallus gallus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.15.18 kidney
-
 Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.18 calcidiol + NADPH + O2 highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol Gallus gallus calcitriol + NADP+ + H2O calcitriol is identical with 1,25-dihydroxycholecalciferol ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.15.18 37
-
 assay at Gallus gallus