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Literature summary extracted from

  • Grieff, M.; Dusso, A.; Mori, T.; Nishii, Y.; Slatopolsky, E.; Brown, A.J.
    22-Oxacalcitriol suppresses 25-hydroxycholecalciferol-1a-hydroxylase in rat kidney (1992), Biochem. Biophys. Res. Commun., 185, 191-196.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.15.18 22-oxacalcitriol vitamin D3 analogue, inhibits in vitro and in vivo Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.15.18 mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.15.18 25-hydroxycholecalciferol + NADPH + O2 Rattus norvegicus central role in calcium regulation calcitriol + NADP+ + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.18 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.15.18 kidney renal cortex Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.15.18 additional information
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.18 25-hydroxycholecalciferol + NADPH + O2 central role in calcium regulation Rattus norvegicus calcitriol + NADP+ + H2O
-
 ?
1.14.15.18 calcidiol + NADPH + O2 highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol Rattus norvegicus calcitriol + NADP+ + H2O calcitriol is identical with 1,25-dihydroxycholecalciferol ?