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Literature summary extracted from

  • Henry, H.L.; Norman, A.W.
    Studies on calciferol metabolism. Regulation of 25-hydroxyvitamin D3-1-hydroxylase in isolated renal mitochondria (1976), Arch. Biochem. Biophys., 172, 582-589.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.15.18 malate supports 1alpha-hydroxylation as electron donor Gallus gallus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.15.18 Ca2+
-
 Gallus gallus
1.14.15.18 ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid
-
 Gallus gallus
1.14.15.18 phosphate
-
 Gallus gallus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.15.18 mitochondrion
-
 Gallus gallus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.18 Gallus gallus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.15.18 kidney
-
 Gallus gallus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.15.18 0.0000031
-
-
 Gallus gallus
1.14.15.18 0.0000048
-
 with malate as electron source Gallus gallus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.18 calcidiol + NADPH + O2 highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol Gallus gallus calcitriol + NADP+ + H2O calcitriol is identical with 1,25-dihydroxycholecalciferol ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.15.18 NADPH
-
 Gallus gallus