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Literature summary extracted from

  • Sun, I.L.; Navas, P.; Crane, F.L.; Morre, D.J.; Löw, H.
    NADH diferric transferrin reductase in liver plasma membrane (1987), J. Biol. Chem., 262, 15915-15921.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.16.1.2 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate detergent, activates Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.16.1.2 adriamycin
-
 Rattus norvegicus
1.16.1.2 amiloride
-
 Rattus norvegicus
1.16.1.2 apotransferrin
-
 Rattus norvegicus
1.16.1.2 Atebrin
-
 Rattus norvegicus
1.16.1.2 Chloroquinone
-
 Rattus norvegicus
1.16.1.2 additional information sensitive to treatment with trypsin Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.16.1.2 0.0061
-
 NADH
-
 Rattus norvegicus
1.16.1.2 0.033
-
 Transferrin[Fe(II)]2
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.16.1.2 cytoplasmic membrane
-
 Rattus norvegicus
-
-
1.16.1.2 additional information low activity in the membranes of Golgi apparatus, endoplasmic reticulum and mitochondria, about 10% of the activity in the plasma membrane Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.16.1.2 K+ potassium phosphate buffer leads to a slightly higher activity than sodium phosphate buffer Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.16.1.2 transferrin[Fe(III)]2 + NADH Rattus norvegicus reduction of diferric transferrin at the cell surface may be an important function for diferric transferrin in stimulation of cell growth transferrin[Fe(II)]2 + NAD+
-
 ?
1.16.1.2 transferrin[Fe(III)]2 + NADH Rattus norvegicus role in iron transport transferrin[Fe(II)]2 + NAD+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.16.1.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.16.1.2 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.16.1.2 0.0057
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.16.1.2 ferritin[Fe(III)] + NADH
-
 Rattus norvegicus ferritin[Fe(II)] + NAD+
-
 ?
1.16.1.2 transferrin[Fe(II)]2 + NAD+ + H+
-
 Rattus norvegicus transferrin[Fe(III)]2 + NADH
-
 r
1.16.1.2 transferrin[Fe(III)]2 + NADH
-
 Rattus norvegicus transferrin[Fe(II)]2 + NAD+
-
 ?
1.16.1.2 transferrin[Fe(III)]2 + NADH reduction of diferric transferrin at the cell surface may be an important function for diferric transferrin in stimulation of cell growth Rattus norvegicus transferrin[Fe(II)]2 + NAD+
-
 ?
1.16.1.2 transferrin[Fe(III)]2 + NADH role in iron transport Rattus norvegicus transferrin[Fe(II)]2 + NAD+
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.16.1.2 8.5
-
-
 Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.16.1.2 7 10 pH 7.0: about 40% of activity maximum, pH 10.0: about 35% of activity maximum Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.16.1.2 NADH preferred electron donor Rattus norvegicus
1.16.1.2 NADPH about 50% of the activity with NADH Rattus norvegicus