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Literature summary extracted from

  • Brock, T.G.; McNish, R.W.; Peters-Golden, M.
    Translocation and leukotriene synthetic capacity of nuclear 5-lipoxygenase in rat basophilic leukemia cells and alveolar macrophages (1995), J. Biol. Chem., 270, 21652-21658.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.34 zileuton
-
 Homo sapiens
1.13.11.34 zileuton
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.13.11.34 cytosol polymorphonuclear leukocytes: translocation of cytosolic enzyme to the nuclear envelope where it interacts with 5-lipoxygenase-activating protein Homo sapiens 5829
-
1.13.11.34 cytosol in basophilic leukemia cells translocation of cytosolic enzyme and the soluble nuclear enzyme to the nuclear envelope where it interacts with 5-lipoxygenase-activating protein Rattus norvegicus 5829
-
1.13.11.34 nuclear envelope polymorphonuclear leukocytes: translocation of cytosolic enzyme to the nuclear envelope where it interacts with 5-lipoxygenase-activating protein Homo sapiens 5635
-
1.13.11.34 nuclear envelope in basophilic leukemia cells translocation of cytosolic enzyme and the soluble nuclear enzyme to the nuclear envelope where it interacts with 5-lipoxygenase-activating protein Rattus norvegicus 5635
-
1.13.11.34 nuclear envelope alvelolar macrophages nuclear soluble enzyme moves to the nucear envelope where it interacts with 5-lipoxygenase-activating protein Rattus norvegicus 5635
-
1.13.11.34 nucleus in basophilic leukemia cells translocation of cytosolic enzyme and the soluble nuclear enzyme to the nuclear envelope where it interacts with 5-lipoxygenase-activating protein Rattus norvegicus 5634
-
1.13.11.34 nucleus alvelolar macrophages nuclear soluble enzyme moves to the nucear envelope where it interacts with 5-lipoxygenase-activating protein Rattus norvegicus 5634
-

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.34 Homo sapiens
-
-
-
1.13.11.34 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.34 alveolar macrophage
-
 Rattus norvegicus
-
1.13.11.34 leukemia cell
-
 Rattus norvegicus
-
1.13.11.34 leukocyte polymorphonuclear Homo sapiens
-
1.13.11.34 leukocyte polymorphonuclear Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.34 arachidonate + O2 i.e. 5,8,11,14-eicosatetraenoic acid Homo sapiens (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate
-
 ?
1.13.11.34 arachidonate + O2 i.e. 5,8,11,14-eicosatetraenoic acid Rattus norvegicus (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate
-
 ?