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Literature summary extracted from

  • Falgueyret, J.P.; Denis, D.; MacDonald, D.; Hutchinson, J.H.; Riendeau, D.
    Characterization of the arachidonate and ATP binding sites of human 5-lipoxygenase using photoaffinity labeling and enzyme immobilization (1995), Biochemistry, 34, 13603-13611.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.13.11.34 adenosine 58% of the activation with ATP Homo sapiens
1.13.11.34 ADP 74% of the activation with ATP Homo sapiens
1.13.11.34 ADP-beta-S 82% of the activation with ATP Homo sapiens
1.13.11.34 AMP 68% of the activation with ATP Homo sapiens
1.13.11.34 AMP-4-nitrophenylphosphate 77% of the activation with ATP Homo sapiens
1.13.11.34 ATP-alphaS 118% of the activation with ATP Homo sapiens
1.13.11.34 ATP-gammaS 80% of the activation with ATP Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.34 L-670,630 IC50: 0.0004 mM Homo sapiens
1.13.11.34 L-689,065 IC50: 0.0003 mM Homo sapiens
1.13.11.34 L-697,198 IC50: 0.00002 mM Homo sapiens
1.13.11.34 L-702,590
-
Homo sapiens
1.13.11.34 L-702,701 IC50: 0.0015 mM Homo sapiens
1.13.11.34 L705,302 IC50: 0.00002 mM Homo sapiens
1.13.11.34 N-(4-chlorophenyl)-N-hydroxy-N'-(3-chlorophenyl)urea IC50: 0.0001 mM Homo sapiens
1.13.11.34 ZD 2138 i.e. CAS: 140841-32-3, IC50: 0.0003 mM Homo sapiens
1.13.11.34 zileuton IC50: 0.01 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.34 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.13.11.34 recombinant enzyme Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.34 arachidonate + O2 i.e. 5,8,11,14-eicosatetraenoic acid Homo sapiens (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate
-
?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.13.11.34 0.00002
-
IC50: 0.00002 mM Homo sapiens L-697,198
1.13.11.34 0.00002
-
IC50: 0.00002 mM Homo sapiens L705,302
1.13.11.34 0.0001
-
IC50: 0.0001 mM Homo sapiens N-(4-chlorophenyl)-N-hydroxy-N'-(3-chlorophenyl)urea
1.13.11.34 0.0003
-
IC50: 0.0003 mM Homo sapiens L-689,065
1.13.11.34 0.0003
-
i.e. CAS: 140841-32-3, IC50: 0.0003 mM Homo sapiens ZD 2138
1.13.11.34 0.0004
-
IC50: 0.0004 mM Homo sapiens L-670,630
1.13.11.34 0.0015
-
IC50: 0.0015 mM Homo sapiens L-702,701
1.13.11.34 0.01
-
IC50: 0.01 mM Homo sapiens zileuton