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Literature summary extracted from

  • Shimizu, T.; Izumi, T.; Seyama, Y.; Tadokoro, K.; Radmark, O.
    Characterization of leukotriene A4 synthase from murine mast cells: evidence for its identity to arachidonate 5-lipoxygenase (1986), Proc. Natl. Acad. Sci. USA, 83, 4175-4179.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.13.11.34 ATP stimulates Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.34 5,6-Methano-leukotriene A4
-
 Mus musculus
1.13.11.34 8,11,13-cis-icosatrienoic acid
-
 Mus musculus
1.13.11.34 AA861
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.13.11.34 Ca2+ required Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.13.11.34 50000 55000 gel filtration Mus musculus
1.13.11.34 75000
-
 x * 75000, SDS-PAGE Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.34 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.13.11.34
-
 Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.34 mast cell bone marrow-derived mast cell line PB-3c Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.13.11.34 additional information
-
-
 Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate + O2
-
 Mus musculus leukotriene A4
-
 ?
1.13.11.34 arachidonate + O2 i.e. 5,8,11,14-eicosatetraenoic acid Mus musculus (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate
-
 ?
1.13.11.34 additional information arachidonate 5-lipoxygenase and leukotriene A5 synthase are identical Mus musculus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.13.11.34 ? x * 75000, SDS-PAGE Mus musculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.13.11.34 0.15
-
 8,11,13-cis-icosatrienoic acid
-
 Mus musculus