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Literature summary extracted from

  • Fuerstenberger, G.; Hagedorn, H.; Jacobi, T.; Besemfelder, E.; Stephan, M.; Lehman, W.D.; Marks, F.
    Characterization of an 8-lipoxygenase activity induced by the phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate in mouse skin in vivo (1991), J. Biol. Chem., 266, 15738-15745.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.13.11.40 EDTA
-
 Mus musculus
1.13.11.40 lecithin
-
 Mus musculus

Application

EC Number Application Comment Organism
1.13.11.40 medicine therapeutic effect of inhibitors of arachidonic acid metabolism on inflammatory skin diseases and epidermal tumors and on tumor development Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.40 beta-mercaptoethanol
-
 Mus musculus
1.13.11.40 Eicosa-5,8,11,14-tetraynoic acid
-
 Mus musculus
1.13.11.40 glutathione 50% inhibition Mus musculus
1.13.11.40 nordihydroguaiaretic acid
-
 Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.13.11.40 0.008
-
 arachidonic acid
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.13.11.40 cytosol
-
 Mus musculus 5829
-
1.13.11.40 microsome
-
 Mus musculus
-
-
1.13.11.40 mitochondrion
-
 Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.40 2 arachidonic acid + 2 O2 Mus musculus pathway of epidermal arachidonate oxygenation 8-hydroxy,9-oxo-eicosa-5Z,11Z,14Z-trienoic acid + 9-oxo-[8,12-cis]-prosta-5Z,10,14Z-trienoic acid + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.40 Mus musculus
-
 mouse, strain NMR1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.40 epidermis cells of the suprabasal compartment of the epidermis Mus musculus
-
1.13.11.40 skin
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.40 2 arachidonic acid + 2 O2 pathway of epidermal arachidonate oxygenation Mus musculus 8-hydroxy,9-oxo-eicosa-5Z,11Z,14Z-trienoic acid + 9-oxo-[8,12-cis]-prosta-5Z,10,14Z-trienoic acid + H2O
-
 ?
1.13.11.40 arachidonic acid + O2
-
 Mus musculus (8R)-8-hydroperoxy-5,9,11,14-eicosatetraenoic acid
-
 ?
1.13.11.40 arachidonic acid + O2 arachidonic acid, enzyme activity only detectable after in vivo treatment with the phorbol ester tumor promoter TPA (12-O-tetradecanoylphorbol-13-acetate) Mus musculus (5Z,8E,11Z,14Z)-8-hydroperoxyicosa-5,8,11,14-tetraenoic acid + (5Z,8E,11Z,14Z)-8-hydroxyicosa-5,8,11,14-tetraenoic acid
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.13.11.40 7.5 8
-
 Mus musculus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.13.11.40 6 9.5
-
 Mus musculus