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Literature summary extracted from
- Purification and characterization of the rat liver gamma-butyrobetaine hydroxylase (1998), Mol. Cell. Biochem., 178, 163-168.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.11.1 | catalase | increase of activity | Rattus norvegicus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.11.1 | 2-oxoglutarate | at concentrations above 1 mM | Rattus norvegicus |  |
| 1.14.11.1 | 3-(2,2,2-trimethylhydrazinium)propionate | complete inhibition at 0.05 mM | Rattus norvegicus | |
| 1.14.11.1 | gamma-butyrobetaine | at concentrations above 0.2 mM | Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.11.1 | 0.08 | - |
gamma-butyrobetaine | - |
Rattus norvegicus | |
| 1.14.11.1 | 0.125 | - |
2-oxo-glutarate | - |
Rattus norvegicus | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.11.1 | Fe2+ | requirement | Rattus norvegicus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.14.11.1 | 43000 | - |
2 * 43000, SDS-PAGE | Rattus norvegicus |
| 1.14.11.1 | 68000 | - |
gel filtration | Rattus norvegicus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.11.1 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.14.11.1 | - |
Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.11.1 | liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.11.1 | 4-trimethylammoniobutanoate + 2-oxoglutarate + O2 | - |
Rattus norvegicus | 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2 | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.14.11.1 | dimer | 2 * 43000, SDS-PAGE | Rattus norvegicus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.11.1 | ascorbate | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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