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Literature summary extracted from

  • Lindstedt, S.; Nordin, I.
    Multiple forms of gamma-butyrobetaine hydroxylase (EC 1.14.11.1) (1984), Biochem. J., 223, 119-127.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.11.1 DL-carnitine
-
Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.11.1 0.1 0.13 2-oxoglutarate gamma-butyrobetaine, values about the same for all three isozymes Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.11.1 cytoplasm
-
Homo sapiens 5737
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.11.1 Fe2+ requirement Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.11.1 64000
-
gel filtration, 3 isozymes, detection by chromatofocusing and anion exchange chromatography Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.1 Homo sapiens
-
three isoforms
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.11.1
-
Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.11.1 kidney
-
Homo sapiens
-
1.14.11.1 liver
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.11.1 1.02 1.74 three isozymes of mammalian enzyme Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.1 4-trimethylammoniobutanoate + 2-oxoglutarate + O2
-
Homo sapiens 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2
-
?

Subunits

EC Number Subunits Comment Organism
1.14.11.1 dimer SDS-PAGE, same value for all three isozymes, dimeric combinations of two subunits Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.11.1 37
-
assay at Homo sapiens