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Literature summary extracted from

  • Lindstedt, G.; Lindstedt, S.
    Cofactor requirements of gamma-butyrobetaine hydroxylase from rat liver (1970), J. Biol. Chem., 245, 4178-4186.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.11.1 2-amino-6,7-dimethyl-4-hydroxy-5,6,7,8-tetrahydropteridine
-
Rattus norvegicus
1.14.11.1 catalase
-
Rattus norvegicus
1.14.11.1 isoascorbate increase of activity Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.11.1 3-trimethylaminopropyl-1-sulfonate
-
Rattus norvegicus
1.14.11.1 arsenite
-
Rattus norvegicus
1.14.11.1 iodoacetate less effective than p-chloromercuriphenylsulfonate Rattus norvegicus
1.14.11.1 Iodosobenzoate less effective than p-chloromercuriphenylsulfonate Rattus norvegicus
1.14.11.1 N-ethylmaleimide less effective than p-chloromercuriphenylsulfonate Rattus norvegicus
1.14.11.1 p-chloromercuribenzoate inactivates enzyme completely at 0.1 mM Rattus norvegicus
1.14.11.1 p-chloromercuriphenylsulfonate inactivates enzyme completely at 0.1 mM Rattus norvegicus
1.14.11.1 structure analogues of gamma-butyrobetaine and 2-oxoglutarate
-
Rattus norvegicus
1.14.11.1 Succinic semialdehyde
-
Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.11.1 additional information
-
additional information
-
Rattus norvegicus
1.14.11.1 0.5
-
2-oxoglutarate
-
Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.11.1 cytoplasm
-
Rattus norvegicus 5737
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.11.1 Fe2+ requirement Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.1 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.11.1
-
Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.11.1 liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.11.1 0.003
-
-
Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.1 4-trimethylammoniobutanoate + 2-oxoglutarate + O2 i.e. gamma-butyrobetaine Rattus norvegicus 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2 i.e. L-carnitine ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.11.1 37
-
assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.11.1 6.7
-
-
Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.14.11.1 6 7.5 half-maximal activity at pH 6.0 and 7.5 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.11.1 2,6-dichlorophenolindophenol
-
Rattus norvegicus
1.14.11.1 ascorbate activation, keeps Fe2+ in the reduced state Rattus norvegicus