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Literature summary extracted from

  • Merriweather, A.; Guenzler, V.; Brenner, M.; Unnasch, T.R.
    Characterization and expression of enzymatically active recombinant filarial prolyl 4-hydroxylase (2001), Mol. Biochem. Parasitol., 116, 185-197.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.11.2 bovine serum albumin activation Onchocerca volvulus
1.14.11.2 catalase activation Onchocerca volvulus
1.14.11.2 dithiothreitol activation Onchocerca volvulus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.11.2 identification of three cDNAs encoding putative alpha subunits of the enzyme, co-expression of one of these with protein-disulfide isomerase in a catalytically active form in an insect system, genomic structure Onchocerca volvulus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.11.2 1,10-phenanthroline
-
 Brugia malayi
1.14.11.2 Coumalic acid
-
 Brugia malayi
1.14.11.2 daunorubicin
-
 Brugia malayi
1.14.11.2 doxorubicin
-
 Brugia malayi
1.14.11.2 Pyridine 2,4-dicarboxylate not inhibitory Brugia malayi

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.11.2 Fe2+
-
 Onchocerca volvulus

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.2 Brugia malayi
-
-
-
1.14.11.2 Onchocerca volvulus Q95W51
-
-
1.14.11.2 Onchocerca volvulus Q95W53
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.2 protocollagen + 2-oxoglutarate + O2
-
 Onchocerca volvulus 4-hydroxyproline containing protocollagen + succinate + CO2
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.11.2 37
-
 assay at Onchocerca volvulus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.11.2 2-oxoglutarate
-
 Onchocerca volvulus
1.14.11.2 ascorbate
-
 Onchocerca volvulus