EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.11.2 | 1,10-phenanthroline | 91% inhibition at 0.02 mM | Rattus norvegicus | |
1.14.11.2 | 2,2'-dipyridyl | - |
Gallus gallus | |
1.14.11.2 | 2,2'-dipyridyl | 87% inhibition at 0.02 mM | Rattus norvegicus | |
1.14.11.2 | antimycin A | 18% inhibition at 0.02 mM | Rattus norvegicus | |
1.14.11.2 | Cupferron | 28% inhibition at 0.02 mM | Rattus norvegicus | |
1.14.11.2 | diethyldithiocarbamate | 10% inhibition at 0.02 mM | Rattus norvegicus | |
1.14.11.2 | EDTA | - |
Gallus gallus | |
1.14.11.2 | EDTA | 64% inhibition at 0.02 mM | Rattus norvegicus | |
1.14.11.2 | gelatin | commercial, inhibitor | Cavia porcellus | |
1.14.11.2 | gelatin | commercial, inhibitor | Gallus gallus | |
1.14.11.2 | gelatin | commercial, inhibitor | Rattus norvegicus | |
1.14.11.2 | Ketomalonate | 100% inhibition at 1 mM, acts by chelating ferrous ion rather than by competing with alpha-ketoglutarate | Cavia porcellus | |
1.14.11.2 | Ketomalonate | 100% inhibition at 1 mM, acts by chelating ferrous ion rather than by competing with alpha-ketoglutarate | Gallus gallus | |
1.14.11.2 | Ketomalonate | 100% inhibition at 1 mM, acts by chelating ferrous ion rather than by competing with alpha-ketoglutarate | Rattus norvegicus | |
1.14.11.2 | malonate | 19% inhibition at 1 mM | Cavia porcellus | |
1.14.11.2 | malonate | 19% inhibition at 1 mM | Gallus gallus | |
1.14.11.2 | malonate | 19% inhibition at 1 mM | Rattus norvegicus | |
1.14.11.2 | oxalate | 34% inhibition at 1 mM | Cavia porcellus | |
1.14.11.2 | oxalate | 34% inhibition at 1 mM | Gallus gallus | |
1.14.11.2 | oxalate | 34% inhibition at 1 mM | Rattus norvegicus | |
1.14.11.2 | propyl gallate | 100% inhibition at 2 mM | Cavia porcellus | |
1.14.11.2 | propyl gallate | 100% inhibition at 2 mM | Gallus gallus | |
1.14.11.2 | propyl gallate | 100% inhibition at 2 mM | Rattus norvegicus | |
1.14.11.2 | succinate | 51% inhibition at 1 mM | Cavia porcellus | |
1.14.11.2 | succinate | 51% inhibition at 1 mM | Gallus gallus | |
1.14.11.2 | succinate | 51% inhibition at 1 mM | Rattus norvegicus | |
1.14.11.2 | trifluorothienylbutanedione | 48% inhibition at 0.05 mM | Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.14.11.2 | 0.03 | - |
O2 | - |
Gallus gallus | |
1.14.11.2 | 0.03 | - |
O2 | - |
Rattus norvegicus | |
1.14.11.2 | 0.03 | - |
peptidyl L-proline | - |
Cavia porcellus |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.14.11.2 | Fe2+ | no compound can replace Fe2+, Km: 0.03 mM | Gallus gallus | |
1.14.11.2 | Fe2+ | no compound can replace Fe2+, Km: 0.03 mM | Cavia porcellus | |
1.14.11.2 | Fe2+ | no compound can replace Fe2+, Km: 0.03 mM | Rattus norvegicus | |
1.14.11.2 | Mg2+ | 3% relative activity with respect to Fe2+ | Gallus gallus | |
1.14.11.2 | Mn2+ | 10% relative activity with respect to Fe2+ | Gallus gallus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.11.2 | Cavia porcellus | - |
- |
- |
1.14.11.2 | Gallus gallus | - |
- |
- |
1.14.11.2 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.11.2 | embryo | - |
Gallus gallus | - |
1.14.11.2 | skin | - |
Gallus gallus | - |
1.14.11.2 | skin | fetus | Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.11.2 | peptidyl L-proline + 2-oxoglutarate + O2 | - |
Cavia porcellus | peptidyl-trans-4-hydroxy-L-proline + succinate + CO2 | - |
r |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.14.11.2 | 30 | - |
- |
Gallus gallus |
1.14.11.2 | 30 | - |
- |
Cavia porcellus |
1.14.11.2 | 30 | - |
- |
Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.14.11.2 | 2-oxoglutarate | no compound can replace alpha-ketoglutarate | Gallus gallus | |
1.14.11.2 | 2-oxoglutarate | no compound can replace alpha-ketoglutarate | Cavia porcellus | |
1.14.11.2 | 2-oxoglutarate | no compound can replace alpha-ketoglutarate | Rattus norvegicus | |
1.14.11.2 | ascorbate | requirement | Gallus gallus | |
1.14.11.2 | ascorbate | requirement | Cavia porcellus | |
1.14.11.2 | ascorbate | requirement | Rattus norvegicus | |
1.14.11.2 | ascorbate | Km: 0.2-1 mM, dependent on the concentrations of alpha-ketoglutarate and Fe2+, reduced pteridines can partially replace ascorbate | Gallus gallus | |
1.14.11.2 | ascorbate | Km: 0.2-1 mM, dependent on the concentrations of alpha-ketoglutarate and Fe2+, reduced pteridines can partially replace ascorbate | Cavia porcellus | |
1.14.11.2 | ascorbate | Km: 0.2-1 mM, dependent on the concentrations of alpha-ketoglutarate and Fe2+, reduced pteridines can partially replace ascorbate | Rattus norvegicus | |
1.14.11.2 | D-isoascorbate | can replace ascorbate | Gallus gallus | |
1.14.11.2 | D-isoascorbate | can replace ascorbate | Cavia porcellus | |
1.14.11.2 | D-isoascorbate | can replace ascorbate | Rattus norvegicus |