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Literature summary extracted from

  • Gunzler, V.; Hanauske-Abel, H.M.; Myllylä, R.; Kaska, D.D.; Hanauske, A.; Kivirikko, K.I.
    Syncatalytic inactivation of prolyl 4-hydroxylase by anthracyclines (1988), Biochem. J., 251, 365-372.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.11.2 bovine serum albumin activation Gallus gallus
1.14.11.2 bovine serum albumin activation Homo sapiens
1.14.11.2 catalase activation Gallus gallus
1.14.11.2 catalase activation Homo sapiens
1.14.11.2 dithiothreitol activation Gallus gallus
1.14.11.2 dithiothreitol activation Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.11.2 daunorubicin irreversible inhibitor, 50% inhibition after 1 h at 0.06 mM, effect dependent on the presence of iron ions Gallus gallus
1.14.11.2 daunorubicin irreversible inhibitor, 50% inhibition after 1 h at 0.06 mM, effect dependent on the presence of iron ions Homo sapiens
1.14.11.2 doxorubicin irreversible inhibitor, 50% inhibition after 1 h at 0.06 mM, effect dependent on the presence of iron ions Gallus gallus
1.14.11.2 doxorubicin irreversible inhibitor, 50% inhibition after 1 h at 0.06 mM, effect dependent on the presence of iron ions Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.11.2 Fe2+
-
 Gallus gallus
1.14.11.2 Fe2+
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.2 Gallus gallus
-
-
-
1.14.11.2 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.11.2 using ammonium sulfate fractionation, affinity chromatography on poly(L-proline) coupled to Sepharose 4B, DEAE-cellulose chromatography, and gel filtration Gallus gallus
1.14.11.2 using ammonium sulfate fractionation, affinity chromatography on poly(L-proline) coupled to Sepharose 4B, DEAE-cellulose chromatography, and gel filtration Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.11.2 embryo
-
 Gallus gallus
-
1.14.11.2 placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.2 (Pro-Pro-Gly)n + 2-oxoglutarate + O2 n: 1,5,10 Gallus gallus (Pro-4-hydroxy-Pro-Gly)n + succinate + CO2 n: 1,5,10 ?
1.14.11.2 (Pro-Pro-Gly)n + 2-oxoglutarate + O2 n: 1,5,10 Homo sapiens (Pro-4-hydroxy-Pro-Gly)n + succinate + CO2 n: 1,5,10 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.11.2 37
-
 assay at Gallus gallus
1.14.11.2 37
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.11.2 ascorbate
-
 Gallus gallus
1.14.11.2 ascorbate
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.11.2 0.04
-
 doxorubicin competitive inhibitor with respect to 2-oxoglutarate, in concentrations not exceeding 0.02 mM, competitive inhibition is also found with respect to ascorbate Gallus gallus
1.14.11.2 0.04
-
 doxorubicin competitive inhibitor with respect to 2-oxoglutarate, in concentrations not exceeding 0.02 mM, competitive inhibition is also found with respect to ascorbate Homo sapiens