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Literature summary extracted from
- Mechanism of inhibition of lysyl hydroxylase activity by the organophosphates malathion and malaoxon (2001), Toxicol. Appl. Pharmacol., 176, 181-186.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.14.11.4 | expression in insect cells using a baculovirus vector | Rattus norvegicus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.11.4 | malaoxon | mechanism of inhibition | Rattus norvegicus |  |
| 1.14.11.4 | malathion | mechanism of inhibition | Rattus norvegicus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.14.11.4 | 85000 | - |
x * 85000, SDS-PAGE and Western blotting | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.11.4 | collagen + 2-oxoglutarate + O2 | Rattus norvegicus | enzyme required during collagen biosynthesis | 5-hydroxylysyl-collagen + succinate + CO2 | - |
? | |
| 1.14.11.4 | collagen + 2-oxoglutarate + O2 | Rattus norvegicus | influence the integrity and stability of collagen | 5-hydroxylysyl-collagen + succinate + CO2 | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.11.4 | Rattus norvegicus | Q63321 | - |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 1.14.11.4 | side-chain modification | hydroxylation of lysyl residue in -X-Lys-Gly | Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.11.4 | collagen + 2-oxoglutarate + O2 | enzyme required during collagen biosynthesis | Rattus norvegicus | 5-hydroxylysyl-collagen + succinate + CO2 | - |
? | |
| 1.14.11.4 | collagen + 2-oxoglutarate + O2 | influence the integrity and stability of collagen | Rattus norvegicus | 5-hydroxylysyl-collagen + succinate + CO2 | - |
? | |
| 1.14.11.4 | peptidyl-L-lysine + 2-oxoglutarate + O2 | - |
Rattus norvegicus | peptidyl-5-hydroxy-L-lysine + succinate + CO2 | hydroxy-L-lysine | ? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.14.11.4 | ? | x * 85000, SDS-PAGE and Western blotting | Rattus norvegicus |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.11.4 | 0.047 | - |
malaoxon | - |
Rattus norvegicus | |
| 1.14.11.4 | 0.059 | - |
malathion | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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