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Literature summary extracted from

  • Hsu, C.A.; Saewert, M.D.; Polsinelli Jr., L.F.; Abbott, M.T.
    Uracils uncoupling of the decarboxylation of alpha-ketoglutarate in the thymine 7-hydroxylase reaction of Neurospora crassa (1981), J. Biol. Chem., 256, 6098-6101.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.11.6 ascorbate
-
 Neurospora crassa
1.14.11.6 catalase
-
 Neurospora crassa

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.11.6 Uracil non-competitive inhibitor Neurospora crassa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.11.6 0.1
-
 thymine
-
 Neurospora crassa
1.14.11.6 0.2
-
 Uracil
-
 Neurospora crassa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.11.6 Fe2+
-
 Neurospora crassa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.11.6 thymine + 2-oxoglutarate + O2 Neurospora crassa
-
 5-hydroxymethyluracil + succinate + CO2
-
 ?
1.14.11.6 thymine + 2-oxoglutarate + O2 Neurospora crassa uc-1
-
 5-hydroxymethyluracil + succinate + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.6 Neurospora crassa
-
 uc-1
-
1.14.11.6 Neurospora crassa uc-1
-
 uc-1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.11.6 mycelium
-
 Neurospora crassa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.6 5-aminouracil + 2-oxoglutarate + O2
-
 Neurospora crassa ? + succinate + CO2
-
 ?
1.14.11.6 5-aminouracil + 2-oxoglutarate + O2
-
 Neurospora crassa uc-1 ? + succinate + CO2
-
 ?
1.14.11.6 thymine + 2-oxoglutarate + O2
-
 Neurospora crassa 5-hydroxymethyluracil + succinate + CO2
-
 ?
1.14.11.6 thymine + 2-oxoglutarate + O2
-
 Neurospora crassa uc-1 5-hydroxymethyluracil + succinate + CO2
-
 ?
1.14.11.6 uracil + 2-oxoglutarate + O2
-
 Neurospora crassa ? + succinate + CO2
-
 ?
1.14.11.6 uracil + 2-oxoglutarate + O2
-
 Neurospora crassa uc-1 ? + succinate + CO2
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.11.6 0.2
-
 Uracil
-
 Neurospora crassa