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Literature summary extracted from
- Benzene-induced uncoupling of naphthalene dioxygenase activity and enzyme inactivation by production of hydrogen peroxide (1999), J. Bacteriol., 181, 2719-2725.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.12.12 | H2O2 | 0.4 mM, complete inactivation of reduced terminal dioxygenase ISPNAP after 10 min in the absence of ferrous iron | Pseudomonas sp. |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.12.12 | Pseudomonas sp. | - |
strain NCIB 9816/11, naphthalene dihydrogenase mutant derived from strain NCIB 9816-4 oxidizing naphthalene to cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.12.12 | benzene + NADH + O2 | 40-50% of O2 is reduced to H2O2 by an uncoupling reaction, only trace amounts of cis-benzene-1,2-dihydrodiol are formed | Pseudomonas sp. | H2O2 + cis-benzene-1,2-dihydrodiol + NAD+ | - |
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