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Literature summary extracted from

  • Pavel, E.G.; Martins, L.J.; Ellis, W.R., Jr.; Solomon, E.I.
    Magnetic circular dichroism studies of exogenous ligand and substrate binding to the non-heme ferrous active site in phthalate dioxygenase (1994), Chem. Biol., 1, 173-183.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.12.7 azide weak, binds to the six-coordinate resting enzyme to form a new six-coordinate Fe2+ species Burkholderia cepacia

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.12.7 Fe2+ mononuclear non-heme Fe2+ active site Burkholderia cepacia
1.14.12.7 Iron enzyme contains a [2Fe-2S] Rieske cluster Burkholderia cepacia

Organism

EC Number Organism UniProt Comment Textmining
1.14.12.7 Burkholderia cepacia
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.12.7 phthalate + NADH + O2
-
Burkholderia cepacia cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+ + H2O
-
?

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.12.7 NADH
-
Burkholderia cepacia