EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.13.34 | (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyeicosa-6,8,10,14-tetraenoate | competitively inhibits leukotriene E4 omega-oxidation | Rattus norvegicus | |
1.14.13.34 | Halothane | induces a transient decrease in leukotriene omega-oxidation both in vivo and in vitro, halothane metabolism-dependent trifluoracetylation of hepatic target proteins might play a role in the inactivation of the enzyme | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.14.13.34 | microsome | - |
Rattus norvegicus | - |
- |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.13.34 | Rattus norvegicus | - |
phenobarbital-treated | - |
1.14.13.34 | Rattus norvegicus | - |
male Sprague Dawley rats | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.13.34 | liver | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.13.34 | (7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate + NADPH + O2 | leukotriene E4 | Rattus norvegicus | 20-hydroxy-leukotriene E4 + NADP+ + H2O | omega-hydroxy-leukotriene E4 | ? | |
1.14.13.34 | N-acetyl-leukotriene E4 + NADPH + O2 | - |
Rattus norvegicus | N-acetyl-omega-hydroxy-leukotriene E4 + NADP+ + H2O | - |
? |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.14.13.34 | NADPH | - |
Rattus norvegicus | |
1.14.13.34 | O2 | - |
Rattus norvegicus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.14.13.34 | 0.08 | - |
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyeicosa-6,8,10,14-tetraenoate | - |
Rattus norvegicus |