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Literature summary extracted from

  • Huwyler, J.; Jedlitschky, G.; Keppler, D.; Gut, J.
    Halothane metabolism. Impairment of hepatic omega-oxidation of leukotrienes in vivo and in vitro (1992), Eur. J. Biochem., 206, 869-897.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.13.34 (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyeicosa-6,8,10,14-tetraenoate competitively inhibits leukotriene E4 omega-oxidation Rattus norvegicus
1.14.13.34 Halothane induces a transient decrease in leukotriene omega-oxidation both in vivo and in vitro, halothane metabolism-dependent trifluoracetylation of hepatic target proteins might play a role in the inactivation of the enzyme Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.13.34 microsome
-
Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.34 Rattus norvegicus
-
phenobarbital-treated
-
1.14.13.34 Rattus norvegicus
-
male Sprague Dawley rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.13.34 liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.34 (7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate + NADPH + O2 leukotriene E4 Rattus norvegicus 20-hydroxy-leukotriene E4 + NADP+ + H2O omega-hydroxy-leukotriene E4 ?
1.14.13.34 N-acetyl-leukotriene E4 + NADPH + O2
-
Rattus norvegicus N-acetyl-omega-hydroxy-leukotriene E4 + NADP+ + H2O
-
?

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.34 NADPH
-
Rattus norvegicus
1.14.13.34 O2
-
Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.13.34 0.08
-
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyeicosa-6,8,10,14-tetraenoate
-
Rattus norvegicus