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Literature summary extracted from

  • Powlowski, J.; Ballou, D.P.; Massey, V.
    Studies of the oxidative half-reaction of anthranilate hydroxylase (deaminating) with native and modified substrates (1990), J. Biol. Chem., 265, 4969-4975.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.35 Cutaneotrichosporon cutaneum
-
 yeast
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.14.13.35 anthranilate + NADPH + H+ + O2 = 2,3-dihydroxybenzoate + NADP+ + NH3 mechanism proposed involving imine formation and hydrolysis during the reaction with the flavin peroxide formed from reduced enzyme flavin and molecular oxygen Cutaneotrichosporon cutaneum
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.35 2-thiobenzoate + NADPH + O2
-
 Cutaneotrichosporon cutaneum ?
-
 ?
1.14.13.35 3-methylanthranilate + NADPH + O2
-
 Cutaneotrichosporon cutaneum ? + NADP+ + NH3 the proposed structure of the product contains a ketone function at the position 2 ?
1.14.13.35 4-fluoroanthranilate + NADPH + O2
-
 Cutaneotrichosporon cutaneum 4-fluoro-2,3-dihydroxybenzoate + NADP+ + NH3
-
 ?
1.14.13.35 5-fluoroanthranilate + NADPH + O2
-
 Cutaneotrichosporon cutaneum 5-fluoro-2,3-dihydroxybenzoate + NADP+ + NH3
-
 ?
1.14.13.35 anthranilate + NADPH + O2
-
 Cutaneotrichosporon cutaneum 2,3-dihydroxybenzoate + NADP+ + NH3
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.35 FAD flavoprotein Cutaneotrichosporon cutaneum
1.14.13.35 NADPH
-
 Cutaneotrichosporon cutaneum