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Literature summary extracted from

  • Behal, V.; Neuzil, J.; Hostalek, Z.
    Effect of tetracycline derivates and some cations on the activity of anhydrotetracycline oxygenase (1983), Biotechnol. Lett., 5, 537-542.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.13.38 ammonium sulfate
-
 Kitasatospora aureofaciens
1.14.13.38 Ca2+ above 2 mM Kitasatospora aureofaciens
1.14.13.38 chlortetracycline
-
 Kitasatospora aureofaciens
1.14.13.38 Co2+
-
 Kitasatospora aureofaciens
1.14.13.38 Cu2+
-
 Kitasatospora aureofaciens
1.14.13.38 Fe3+
-
 Kitasatospora aureofaciens
1.14.13.38 Mg2+ above 1 mM Kitasatospora aureofaciens
1.14.13.38 Mn2+
-
 Kitasatospora aureofaciens
1.14.13.38 Ni2+
-
 Kitasatospora aureofaciens
1.14.13.38 oxytetracycline
-
 Kitasatospora aureofaciens
1.14.13.38 tetracycline
-
 Kitasatospora aureofaciens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.13.38 0.022
-
 anhydrotetracycline
-
 Kitasatospora aureofaciens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.13.38 cytoplasm
-
 Kitasatospora aureofaciens 5737
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.13.38 Ca2+ increase of activity at 0.1-2 mM Kitasatospora aureofaciens
1.14.13.38 Co2+ increase of activity Kitasatospora aureofaciens
1.14.13.38 Cu2+ increase of activity Kitasatospora aureofaciens
1.14.13.38 Fe2+ increase of activity Kitasatospora aureofaciens
1.14.13.38 Fe3+ increase of activity Kitasatospora aureofaciens
1.14.13.38 Mg2+ increase of activity at 0.1-1 mM Kitasatospora aureofaciens
1.14.13.38 Mn2+ increase of activity Kitasatospora aureofaciens
1.14.13.38 Ni2+ increase of activity Kitasatospora aureofaciens

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.38 Kitasatospora aureofaciens
-
 50/137, UV-light induced mutant of strain 84/25
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.13.38 partial Kitasatospora aureofaciens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.38 anhydrooxytetracycline + NADPH + O2
-
 Kitasatospora aureofaciens ?
-
 ?
1.14.13.38 anhydrotetracycline + NADPH + O2
-
 Kitasatospora aureofaciens 12-dehydrotetracycline + NADP+ + H2O
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.38 NADPH
-
 Kitasatospora aureofaciens