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Literature summary extracted from

  • Martinez, A.; Olafsdottir, S.; Haavik, J.; Flatmark, T.
    Inactivation of purified phenylalanine hydroxylase by dithiothreitol (1992), Biochem. Biophys. Res. Commun., 182, 92-98.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.16.1 2-mercaptoethanol 2 mM, 80% inhibition Rattus norvegicus
1.14.16.1 ascorbate 2 mM, 78% inhibition Rattus norvegicus
1.14.16.1 dithiothreitol 2 mM, 94% inhibition, dithiothreitol induces the dissociation of iron from the enzyme, catalase and phenylalanine partially protect from inhibition Rattus norvegicus
1.14.16.1 L-cysteine 2 mM, 42% inhibition Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.16.1 Iron 1 iron atom per subunit, fully active enzyme has non-heme high-spin ferric iron coordinated at the active site Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.14.16.1 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.16.1 liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.16.1 L-phenylalanine + tetrahydrobiopterin + O2
-
Rattus norvegicus L-tyrosine + dihydrobiopterin + H2O
-
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Cofactor

EC Number Cofactor Comment Organism Structure
1.14.16.1 tetrahydrobiopterin
-
Rattus norvegicus