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Literature summary extracted from
- Kinetic properties of tyrosine hydroxylase purified from bovine adrenal medulla and bovine caudate nucleus (1982), Biochim. Biophys. Acta, 706, 188-196.
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.16.2 | additional information | - |
additional information | Km dependence on substrate concentrations | Bos taurus |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.14.16.2 | 60000 | - |
4 * 60000, SDS-PAGE | Bos taurus |
| 1.14.16.2 | 280000 | - |
gel filtration | Bos taurus |
| 1.14.16.2 | 280000 | - |
form I | Bos taurus |
| 1.14.16.2 | 310000 | - |
from caudate nucleus, gel filtration | Bos taurus |
| 1.14.16.2 | 390000 | - |
from adrenal medulla, form II, gel filtration | Bos taurus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.16.2 | Bos taurus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.14.16.2 | 2 forms with different MW in adrenal medulla | Bos taurus |
| 1.14.16.2 | from caudate nuclei | Bos taurus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.16.2 | adrenal medulla | - |
Bos taurus | - |
| 1.14.16.2 | caudate nucleus | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.14.16.2 | 0.41 | - |
purified enzyme | Bos taurus |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 1.14.16.2 | -80°C, highly purified enzyme, 2 months | Bos taurus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.16.2 | L-tyrosine + 6-methyltetrahydropterin + O2 | - |
Bos taurus | ? | - |
? |  |
| 1.14.16.2 | L-tyrosine + tetrahydrobiopterin + O2 | - |
Bos taurus | 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O | 3,4-dihydroxy-L-phenylalanine is identical with dopa | ? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.14.16.2 | tetramer | 4 * 60000, SDS-PAGE | Bos taurus |
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Release 2023.1 (January 2023)
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