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Literature summary extracted from

  • Nagatsu, T.; Levitt, M.; Udenfriend, S.
    Tyrosine hydroxylase.The initial step in norepinephrine biosynthesis (1964), J. Biol. Chem., 239, 2910-2917.
    View publication on PubMed

General Stability

EC Number General Stability Organism
1.14.16.2 0.1 M 2-mercaptoethanol is necessary for stabilization during purification Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.16.2 2,2'-dipyridyl
-
 Bos taurus
1.14.16.2 2-methyl-L-tyrosine
-
 Bos taurus
1.14.16.2 3,4-dihydroxybenzoic acid
-
 Bos taurus
1.14.16.2 alpha-Propyldihydroxyphenylacetamide
-
 Bos taurus
1.14.16.2 dopamine
-
 Bos taurus
1.14.16.2 L-Dopa
-
 Bos taurus
1.14.16.2 norepinephrine
-
 Bos taurus
1.14.16.2 phenylalanine L-isomer, not D-isomer Bos taurus
1.14.16.2 phenylalanine
-
 Cavia porcellus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.16.2 cytosol
-
 Bos taurus 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.16.2 Iron Fe2+ activates Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.16.2 L-tyrosine + tetrahydrobiopterin + O2 Cavia porcellus
-
 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O
-
 ?
1.14.16.2 L-tyrosine + tetrahydrobiopterin + O2 Bos taurus first step in biosynthesis of catecholamines such as norepinephrine, epinephrine and dopamine 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.16.2 Bos taurus
-
-
-
1.14.16.2 Cavia porcellus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.16.2
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.16.2 adrenal medulla
-
 Bos taurus
-
1.14.16.2 brain
-
 Bos taurus
-
1.14.16.2 nervous system sympathetic, innervated Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.16.2 L-tyrosine + 2-amino-4-hydroxy-6,7-dimethyltetrahydropterin + O2
-
 Bos taurus ?
-
 ?
1.14.16.2 L-tyrosine + tetrahydrobiopterin + O2
-
 Cavia porcellus 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O
-
 ?
1.14.16.2 L-tyrosine + tetrahydrobiopterin + O2
-
 Cavia porcellus 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O 3,4-dihydroxy-L-phenylalanine is identical with dopa ?
1.14.16.2 L-tyrosine + tetrahydrobiopterin + O2
-
 Bos taurus 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O 3,4-dihydroxy-L-phenylalanine is identical with dopa ?
1.14.16.2 L-tyrosine + tetrahydrobiopterin + O2 first step in biosynthesis of catecholamines such as norepinephrine, epinephrine and dopamine Bos taurus 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O
-
 ?
1.14.16.2 L-tyrosine + tetrahydrofolic acid + O2
-
 Bos taurus ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.16.2 6.2
-
-
 Bos taurus