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Literature summary extracted from
- A structural approach into human tryptophan hydroxylase and its implications for the regulation of serotonin biosynthesis (2001), Curr. Med. Chem., 8, 1077-1091.
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 1.14.16.4 | modeled structure based on the known crystal structures of phenylalanine hydroxylase and tyrosine hydroxylase | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.16.4 | 3,4-methylenedioxymethamphetamine | inactivation of the enzyme | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.16.4 | L-tryptophan + tetrahydropteridine + O2 | Homo sapiens | initial and uncommited step in the biosynthesis of melatonin | 5-hydroxy-L-tryptophan + dihydropteridine + H2O | - |
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Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.16.4 | Homo sapiens | - |
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- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.16.4 | L-tryptophan + tetrahydropteridine + O2 | initial and uncommited step in the biosynthesis of melatonin | Homo sapiens | 5-hydroxy-L-tryptophan + dihydropteridine + H2O | - |
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Release 2023.1 (January 2023)
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