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Literature summary extracted from

  • Koizumi, S.; Matsushima, Y.; Nagatsu, T.; Linuma, H.; Takeuchi, T.; Umezawa, H.
    3,4-Dihydroxystyrene, a novel microbial inhibitor for phenylalanine hydroxylase and other pteridine-dependent monooxygenases (1984), Biochim. Biophys. Acta, 789, 111-118.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.16.1 3,4-dihydroxyphenylpropane 0.0016 mM, 50% inhibition Rattus norvegicus
1.14.16.1 3,4-Dihydroxyphenylpropionic acid 0.24 mM, 50% inhibition Rattus norvegicus
1.14.16.1 3,4-Dihydroxystyrene 0.0005-0.005 mM, 50% inhibition, noncompetitive vs. 6,7-dimethyltetrahydropterin and L-phenylalanine Rattus norvegicus
1.14.16.1 catechol 0.033 mM, 50% inhibition Rattus norvegicus
1.14.16.1 dopamine 0.025 mM, 50% inhibition Rattus norvegicus
1.14.16.2 3,4-Dihydroxystyrene
-
 Rattus norvegicus
1.14.16.4 3,4-Dihydroxystyrene
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.14.16.1 Rattus norvegicus
-
-
-
1.14.16.2 Rattus norvegicus
-
-
-
1.14.16.4 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.16.1 liver
-
 Rattus norvegicus
-
1.14.16.2 adrenal gland
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.16.1 L-phenylalanine + tetrahydrobiopterin + O2
-
 Rattus norvegicus L-tyrosine + dihydrobiopterin + H2O
-
 ?
1.14.16.2 L-tyrosine + tetrahydrobiopterin + O2
-
 Rattus norvegicus 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O 3,4-dihydroxy-L-phenylalanine is identical with dopa ?
1.14.16.4 L-tryptophan + tetrahydropteridine + O2
-
 Rattus norvegicus 5-hydroxy-L-tryptophan + dihydropteridine + H2O
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.16.1 tetrahydrobiopterin
-
 Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.16.1 0.00027
-
 3,4-Dihydroxystyrene with 15 min preincubation Rattus norvegicus
1.14.16.1 0.0032
-
 3,4-Dihydroxystyrene without preincubation Rattus norvegicus