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Literature summary extracted from

  • Colombo, G.; Rajashekhar, B.; Giedroc, D.P.; Villafranca, J.J.
    Mechanism-based inhibitors of dopamine beta-hydroxylase: inhibition by 2-bromo-3-(p-hydroxyphenyl)-1-propene (1984), Biochemistry, 23, 3590-3598.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.17.1 2-Bromo-3-(p-hydroxyphenyl)-1-propene mechanism-based inhibition Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.17.1 5.9
-
 2-Bromo-3-(p-hydroxyphenyl)-1-propene
-
 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.17.1 chromaffin granule
-
 Bos taurus 42583
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.17.1 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.17.1 adrenal medulla
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.17.1 2-bromo-3-(p-hydroxyphenyl)-1-propene + ascorbate + O2
-
 Bos taurus 2-bromo-3-hydroxy-3-(p-hydroxyphenyl)-1-propene + H2O
-
 ?
1.14.17.1 3,4-dihydroxyphenethylamine + ascorbate + O2
-
 Bos taurus noradrenaline + dehydroascorbate + H2O norepinephrine ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.14.17.1 0.223
-
 2-Bromo-3-(p-hydroxyphenyl)-1-propene
-
 Bos taurus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.17.1 4.9
-
 2-Bromo-3-(p-hydroxyphenyl)-1-propene
-
 Bos taurus