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Literature summary extracted from

  • Townes, S.; Titone, C.; Rosenberg, R.C.
    Inhibition of dopamine beta-hydroxylase by bidentate chelating agents (1990), Biochim. Biophys. Acta, 1037, 240-247.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.17.1 (1H)-Imidazole-4-acetic acid
-
 Bos taurus
1.14.17.1 1(2H)-Phthalazine hydrazone hydralazine Bos taurus
1.14.17.1 1-Isoquinolinecarboxylic acid
-
 Bos taurus
1.14.17.1 2(1H)-Pyridinone hydrazone 2-hydrazinopyridine Bos taurus
1.14.17.1 2,2'-Bi-(1H)-imidazole 2,2'-biimidazole Bos taurus
1.14.17.1 Quinoline-2-carboxylic acid
-
 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.17.1 soluble
-
 Bos taurus
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.17.1 Bos taurus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.14.17.1 dopamine + 2 ascorbate + O2 = noradrenaline + 2 monodehydroascorbate + H2O mechanism Bos taurus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.17.1 adrenal gland
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.17.1 3,4-dihydroxyphenethylamine + ascorbate + O2
-
 Bos taurus noradrenaline + dehydroascorbate + H2O norepinephrine ?
1.14.17.1 tyramine + ascorbate + O2
-
 Bos taurus octopamine + dehydroascorbate + H2O
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.17.1 0.0009
-
 1-Isoquinolinecarboxylic acid
-
 Bos taurus
1.14.17.1 0.0019
-
 2(1H)-Pyridinone hydrazone
-
 Bos taurus
1.14.17.1 0.0057
-
 1(2H)-Phthalazine hydrazone
-
 Bos taurus
1.14.17.1 0.021
-
 2,2'-Bi-(1H)-imidazole
-
 Bos taurus
1.14.17.1 0.14
-
 Quinoline-2-carboxylic acid
-
 Bos taurus
1.14.17.1 0.8
-
 1-Isoquinolinecarboxylic acid
-
 Bos taurus