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Literature summary extracted from
- The enzymatic conversion of 3,4-dihydroxyphenylethylamine to norepinephrine (1960), J. Biol. Chem., 235, 2080-2086.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.17.1 | ascorbic acid | complete dependance on added ascorbate, e.g. isoascorbate, glucoascorbate, D-ascorbate | Bos taurus |  |
| 1.14.17.1 | fumarate | - |
Bos taurus | |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.17.1 | ascorbic acid oxidase | - |
Bos taurus | |
| 1.14.17.1 | KCN | - |
Bos taurus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.17.1 | 6 | - |
ascorbate | - |
Bos taurus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.17.1 | Bos taurus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.14.17.1 | partial | Bos taurus |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 1.14.17.1 | dopamine + 2 ascorbate + O2 = noradrenaline + 2 monodehydroascorbate + H2O | stoichiometry | Bos taurus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.17.1 | adrenal medulla | - |
Bos taurus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.17.1 | 3,4-dihydroxyphenethylamine + ascorbate + O2 | - |
Bos taurus | noradrenaline + dehydroascorbate + H2O | norepinephrine | ? | |
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Release 2023.1 (January 2023)
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