BRENDA - Enzyme Database show

DELTA6-, stearoyl CoA-, and DELTA5-desaturase enzymes are expressed in beta-cells and are altered by increases in exogenous PUFA concentrations

Ramanadham, S.; Zhang, S.; Ma, Z.; Wohltmann, M.; Bohrer, A.; Hsu, F.F.; Turk, J.; Biochim. Biophys. Acta 1580, 40-56 (2002)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
1.14.19.3
human sequence determined
Homo sapiens
1.14.19.3
RT-PCR analysis of INS-1 beta-cell content of mRNA, primer pairs basedon known rat sequence
Rattus norvegicus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.14.19.3
linoleic acid + AH2 + O2
Homo sapiens
important for the generation of unsaturated fatty acids, DELTA6-desaturase required for the conversion of dietary linoleic acid to arachidonic acid
gamma-linolenic acid + A + H2O
-
-
?
1.14.19.3
linoleic acid + AH2 + O2
Rattus norvegicus
important for the generation of unsaturated fatty acids, DELTA6-desaturase required for the conversion of dietary linoleic acid to arachidonic acid
gamma-linolenic acid + A + H2O
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.14.19.3
Homo sapiens
-
human
-
1.14.19.3
Rattus norvegicus
-
INS-1 beta-cells
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.14.19.3
linoleic acid + AH2 + O2
important for the generation of unsaturated fatty acids, DELTA6-desaturase required for the conversion of dietary linoleic acid to arachidonic acid
438423
Homo sapiens
gamma-linolenic acid + A + H2O
-
-
-
?
1.14.19.3
linoleic acid + AH2 + O2
important for the generation of unsaturated fatty acids, DELTA6-desaturase required for the conversion of dietary linoleic acid to arachidonic acid
438423
Rattus norvegicus
gamma-linolenic acid + A + H2O
-
-
-
?
1.14.19.3
linolenic acid + AH2 + O2
-
438423
Homo sapiens
arachidonic acid + A + H2O
-
438423
Homo sapiens
?
1.14.19.3
linolenic acid + AH2 + O2
-
438423
Rattus norvegicus
arachidonic acid + A + H2O
-
438423
Rattus norvegicus
?
1.14.19.3
octadeca-9,12-dienoic acid + AH2 + O2
-
438423
Homo sapiens
gamma-linolenic acid + A + H2O
-
438423
Homo sapiens
?
1.14.19.3
octadeca-9,12-dienoic acid + AH2 + O2
-
438423
Rattus norvegicus
gamma-linolenic acid + A + H2O
-
438423
Rattus norvegicus
?
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
1.14.19.3
human sequence determined
Homo sapiens
1.14.19.3
RT-PCR analysis of INS-1 beta-cell content of mRNA, primer pairs basedon known rat sequence
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.14.19.3
linoleic acid + AH2 + O2
Homo sapiens
important for the generation of unsaturated fatty acids, DELTA6-desaturase required for the conversion of dietary linoleic acid to arachidonic acid
gamma-linolenic acid + A + H2O
-
-
?
1.14.19.3
linoleic acid + AH2 + O2
Rattus norvegicus
important for the generation of unsaturated fatty acids, DELTA6-desaturase required for the conversion of dietary linoleic acid to arachidonic acid
gamma-linolenic acid + A + H2O
-
-
?
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.14.19.3
linoleic acid + AH2 + O2
important for the generation of unsaturated fatty acids, DELTA6-desaturase required for the conversion of dietary linoleic acid to arachidonic acid
438423
Homo sapiens
gamma-linolenic acid + A + H2O
-
-
-
?
1.14.19.3
linoleic acid + AH2 + O2
important for the generation of unsaturated fatty acids, DELTA6-desaturase required for the conversion of dietary linoleic acid to arachidonic acid
438423
Rattus norvegicus
gamma-linolenic acid + A + H2O
-
-
-
?
1.14.19.3
linolenic acid + AH2 + O2
-
438423
Homo sapiens
arachidonic acid + A + H2O
-
438423
Homo sapiens
?
1.14.19.3
linolenic acid + AH2 + O2
-
438423
Rattus norvegicus
arachidonic acid + A + H2O
-
438423
Rattus norvegicus
?
1.14.19.3
octadeca-9,12-dienoic acid + AH2 + O2
-
438423
Homo sapiens
gamma-linolenic acid + A + H2O
-
438423
Homo sapiens
?
1.14.19.3
octadeca-9,12-dienoic acid + AH2 + O2
-
438423
Rattus norvegicus
gamma-linolenic acid + A + H2O
-
438423
Rattus norvegicus
?