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Literature summary extracted from

  • Barnett, J.; Chow, J.; Ives, D.; Chiou, M.; Mackenzie, R.; Osen, E.; Nguyen, B.; Tsing, S.; Bach, C.; Freire, J.; et al.
    Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system (1994), Biochim. Biophys. Acta, 1209, 130-139.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.99.1 anirolac isozyme 1, 50% inhibition at 0.0007 mM, isozyme 2, 50% inhibition at 0.009 mM Homo sapiens
1.14.99.1 diclofenac isozyme 1, 50% inhibition at 0.0009 mM, isozyme 2, 50% inhibition at 0.0015 mM Homo sapiens
1.14.99.1 fenclofenac isozyme 1, 50% inhibition at 0.007 mM, isozyme 2, 50% inhibition at 0.004 mM Homo sapiens
1.14.99.1 flurbiprofen isozyme 1, 50% inhibition at 40 nM, isozyme 2, 50% inhibition at 500 nM Homo sapiens
1.14.99.1 Ibuprofen isozyme 1, 50% inhibition at 0.0026 mM, isozyme 2, 50% inhibition at 0.0015 mM Homo sapiens
1.14.99.1 indomethacin isozyme 1, 50% inhibition at 0.0017 mM, isozyme 2, 50% inhibition at 0.025 mM Homo sapiens
1.14.99.1 Ketoprofen isozyme 1, 50% inhibition at 0.0005 mM, isozyme 2, 50% inhibition at 0.0025 mM Homo sapiens
1.14.99.1 Mefenamic acid isozyme 1, 50% inhibition at 0.01 mM, isozyme 2, 50% inhibition at 0.0003 mM Homo sapiens
1.14.99.1 N-[2-cyclohexyloxy-4-nitrophenyl]methanesulfonamide isozyme 1, 50% inhibition at 0.075 mM, isozyme 2, 50% inhibition at 0.002 mM Homo sapiens
1.14.99.1 naproxen isozyme 1, 50% inhibition at 0.0006 mM, isozyme 2, 50% inhibition at 0.002 mM Homo sapiens
1.14.99.1 niflumic acid isozyme 1, 50% inhibition at 0.016 mM, isozyme 2, 50% inhibition at 0.0001 mM Homo sapiens
1.14.99.1 nimesulide isozyme 1, 50% inhibition at 0.07 mM, isozyme 2, 50% inhibition at 0.0013 mM Homo sapiens
1.14.99.1 suprofen isozyme 1, 50% inhibition at 0.0005 mM, isozyme 2, 50% inhibition at 0.002mM Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.99.1 0.0045
-
 arachidonic acid isozyme 1 Homo sapiens
1.14.99.1 0.005
-
 arachidonic acid isozyme 2 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.99.1 75000
-
 x * 75000, SDS-PAGE, isozyme 1 and 2 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.14.99.1 Homo sapiens
-
 recombinant isozymes 1 and 2
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.14.99.1 glycoprotein both isozyme 1 and 2 Homo sapiens

Subunits

EC Number Subunits Comment Organism
1.14.99.1 ? x * 75000, SDS-PAGE, isozyme 1 and 2 Homo sapiens