Literature summary extracted from

Alvear, M.; Jabalquinto, A.M.; Cardemil, E.
Inactivation of chicken liver mevalonate 5-diphosphate decarboxylase by sulfhydryl-directed reagents: evidence of a functional dithiol (1989), Biochim. Biophys. Acta, 994, 7-11.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
4.1.1.33	additional information	the enzyme posseses a functional dithiol that is important for substrate binding	Gallus gallus

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
4.1.1.33	5,5'-dithiobis(2-nitrobenzoate)	presence of substrate ATP or mevalonate 5-diphosphate protects effectively against inactivation	Gallus gallus
4.1.1.33	arsenite-2,3-dimercapto-1-propanol	-	Gallus gallus
4.1.1.33	Cd2+	-	Gallus gallus
4.1.1.33	Diamide	-	Gallus gallus
4.1.1.33	methylmethanethiosulfonate	presence of substrate ATP or mevalonate 5-diphosphate protects effectively against inactivation	Gallus gallus
4.1.1.33	Phenylarsine oxide	-	Gallus gallus

Organism

EC Number	Organism	UniProt	Comment	Textmining
4.1.1.33	Gallus gallus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
4.1.1.33	liver	-	Gallus gallus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4.1.1.33	ATP + 5-diphosphomevalonate	-	Gallus gallus	ADP + phosphate + isopentenyl diphosphate + CO2	-	?

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Release 2023.1 (January 2023)