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Literature summary extracted from

  • Shibahara, M.; Moody, J.A.; Smith, L.L.
    Microbial hydroxylations. V. 11alpha-hydroxylation of progesterone by cell-free preparations of Aspergillus ochraceus (1979), Biochim. Biophys. Acta, 202, 172-179.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.99.14 11alpha-hydroxyprogesterone induced by Aspergillus ochraceus
1.14.99.14 nortestosterone induced by Aspergillus ochraceus
1.14.99.14 progesterone best inducer Aspergillus ochraceus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.99.14 progesterone + NADPH + O2 Priestia megaterium
-
 11alpha-hydroxyprogesterone + NADP+ + H2O
-
 ?
1.14.99.14 progesterone + NADPH + O2 Aspergillus ochraceus
-
 11alpha-hydroxyprogesterone + NADP+ + H2O
-
 ?
1.14.99.14 progesterone + NADPH + O2 Aspergillus ochraceus NRRL 405
-
 11alpha-hydroxyprogesterone + NADP+ + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.99.14 Aspergillus ochraceus
-
-
-
1.14.99.14 Aspergillus ochraceus NRRL 405
-
-
-
1.14.99.14 Priestia megaterium
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.99.14 mycelium
-
 Aspergillus ochraceus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.99.14 11alpha-hydroxyprogesterone + NADPH + O2
-
 Aspergillus ochraceus 6beta,11alpha-dihydroxyprogesterone
-
 ?
1.14.99.14 11alpha-hydroxyprogesterone + NADPH + O2
-
 Aspergillus ochraceus NRRL 405 6beta,11alpha-dihydroxyprogesterone
-
 ?
1.14.99.14 19-nortestosterone + NADPH + O2
-
 Aspergillus ochraceus 11alpha-hydroxy-19-nortestosterone + NADP+ + H2O
-
 ?
1.14.99.14 19-nortestosterone + NADPH + O2
-
 Aspergillus ochraceus NRRL 405 11alpha-hydroxy-19-nortestosterone + NADP+ + H2O
-
 ?
1.14.99.14 additional information 11alpha-hydroxylase induced by progesterone or 19-nortestosterone is free from associated 6beta-hydroxylase or 17beta-hydroxysteroid dehydrogenase activity, but induction with 11alpha-hydroxyprogesterone yields an enzyme with both 6beta- and 11alpha-hydroxylase activity Aspergillus ochraceus ?
-
 ?
1.14.99.14 additional information 11alpha-hydroxylase induced by progesterone or 19-nortestosterone is free from associated 6beta-hydroxylase or 17beta-hydroxysteroid dehydrogenase activity, but induction with 11alpha-hydroxyprogesterone yields an enzyme with both 6beta- and 11alpha-hydroxylase activity Aspergillus ochraceus NRRL 405 ?
-
 ?
1.14.99.14 progesterone + NADPH + O2
-
 Priestia megaterium 11alpha-hydroxyprogesterone + NADP+ + H2O
-
 ?
1.14.99.14 progesterone + NADPH + O2
-
 Aspergillus ochraceus 11alpha-hydroxyprogesterone + NADP+ + H2O
-
 ?
1.14.99.14 progesterone + NADPH + O2
-
 Aspergillus ochraceus NRRL 405 11alpha-hydroxyprogesterone + NADP+ + H2O
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.14.99.14 30
-
 loses potency at higher temperatures Aspergillus ochraceus