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Literature summary extracted from
- Evidence for a mixed function oxidase in the biosynthesis of ethanolamine plasmalogens from 1-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine (1972), J. Biol. Chem., 247, 5442-5447.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.19.77 | ATP | stimulates the conversion by a factor of 4 | Rattus norvegicus |  |
| 1.14.19.77 | Mg2+ | stimulates the conversion by a factor of 2 | Rattus norvegicus | |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.19.77 | CN- | - |
Rattus norvegicus | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.19.77 | Mg2+ | - |
Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.19.77 | O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + electron donor + O2 | Rattus norvegicus | - |
O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + oxidized electron donor + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.19.77 | Rattus norvegicus | - |
Charles River adult rats, strain CD | - |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 1.14.19.77 | a plasmanylethanolamine + 2 ferrocytochrome b5 + O2 + 2 H+ = a plasmenylethanolamine + 2 ferricytochrome b5 + 2 H2O | mixed function oxidase | Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.19.77 | sarcoma cell | Fischer R-3259 sarcoma | Rattus norvegicus | - |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 1.14.19.77 | -23°C, postmitochondrial supernatant stable for two weeks | Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.19.77 | O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + electron donor + O2 | - |
Rattus norvegicus | O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + oxidized electron donor + H2O | - |
? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.14.19.77 | 37 | - |
enzyme assay | Rattus norvegicus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.19.77 | cytochrome b5 | could be involved | Rattus norvegicus | |
| 1.14.19.77 | NADH | - |
Rattus norvegicus | |
| 1.14.19.77 | NADPH | or NADH | Rattus norvegicus | |
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Release 2023.1 (January 2023)
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