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Literature summary extracted from

  • Clement, P.M.J.; Hanauske-Abel, H.M.; Wolff, E.C.; Kleinman, H.K.; Park, M.H.
    The antifungal drug ciclopirox inhibits deoxyhypusine and proline hydroxylation, endothelial cell growth and angiogenesis in vitro (2002), Int. J. Cancer, 100, 491-498.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.14.99.29 medicine ciclopirox inhibits cell proliferation and angiogenesis in vitro Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.99.29 2,2'-dipyridyl IC50 0.026 mM Homo sapiens
1.14.99.29 ciclopirox IC50 0.005 mM, complete inhibition above 0.01 mM Homo sapiens
1.14.99.29 deferiprone IC50 0.117 mM Homo sapiens
1.14.99.29 desferrioxamine B IC50 0.016 mM Homo sapiens
1.14.99.29 mimosine IC50 0.191 mM Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.14.99.29 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.99.29 umbilical vein endothelium
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.99.29 N'-(4-aminobutyl)lysine + electron donor + O2 i.e. deoxyhypusine Homo sapiens N'-(4-amino-2-hydroxybutyl)lysine + oxidized electron donor + H2O i.e. hypusine ?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.99.29 0.005
-
 IC50 0.005 mM, complete inhibition above 0.01 mM Homo sapiens ciclopirox
1.14.99.29 0.016
-
 IC50 0.016 mM Homo sapiens desferrioxamine B
1.14.99.29 0.026
-
 IC50 0.026 mM Homo sapiens 2,2'-dipyridyl
1.14.99.29 0.117
-
 IC50 0.117 mM Homo sapiens deferiprone
1.14.99.29 0.191
-
 IC50 0.191 mM Homo sapiens mimosine