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Literature summary extracted from

  • Yoshinaga, T.; Sassa, S.; Kappas, A.
    The oxidative degradation of heme c by the microsomal heme oxygenase system (1982), J. Biol. Chem., 257, 7803-7807.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.14.18 0.0009
-
 heme b spleen heme oxygenase Bos taurus
1.14.14.18 0.029
-
 heme c spleen heme oxygenase Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.18 microsome
-
 Rattus norvegicus
-
-
1.14.14.18 microsome
-
 Bos taurus
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.18 Bos taurus
-
-
-
1.14.14.18 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.18 liver
-
 Rattus norvegicus
-
1.14.14.18 liver
-
 Bos taurus
-
1.14.14.18 spleen
-
 Rattus norvegicus
-
1.14.14.18 spleen
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.18 heme + electron donor + O2 enzyme catalyzes oxidative cleavage of both heme b and heme c Rattus norvegicus biliverdin + Fe2+ + CO + oxidized eletron donor + H2O
-
 ?
1.14.14.18 heme + electron donor + O2 enzyme catalyzes oxidative cleavage of both heme b and heme c Bos taurus biliverdin + Fe2+ + CO + oxidized eletron donor + H2O
-
 ?
1.14.14.18 heme c + NADPH + H+ + O2
-
 Bos taurus biliverdin c + Fe2+ + CO + NAD+ + H2O
-
 r