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Literature summary extracted from
- Oxidation of heme c derivatives by purified heme oxygenase. Evidence for the presence of one molecular species of heme oxygenase in the rat liver (1982), J. Biol. Chem., 257, 9944-9952.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.18 | CO | - |
Rattus norvegicus |  |
| 1.14.14.18 | KCN | - |
Rattus norvegicus | |
| 1.14.14.18 | NaN3 | - |
Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.14.18 | 0.0009 | - |
protoheme | - |
Rattus norvegicus | |
| 1.14.14.18 | 0.01 | - |
hematoheme | - |
Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.14.18 | microsome | - |
Rattus norvegicus | - |
- |
| 1.14.14.18 | mitochondrion | liver, 7% of microsomal activity | Rattus norvegicus | 5739 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.14.18 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.14.18 | liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.14.14.18 | additional information | - |
- |
Rattus norvegicus |
| 1.14.14.18 | 0.05 | - |
hematoheme oxidation | Rattus norvegicus |
| 1.14.14.18 | 0.052 | - |
protoheme oxidation | Rattus norvegicus |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 1.14.14.18 | -30°C, several weeks, no loss of activity | Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.18 | hematoheme + NADPH + H+ + O2 | - |
Rattus norvegicus | hematobiliverdin Fe2+ + CO + NAD+ + H2O | - |
r | |
| 1.14.14.18 | heme + electron donor + O2 | electron donor NADH | Rattus norvegicus | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
| 1.14.14.18 | heme + electron donor + O2 | enzyme oxidizes protoheme, hematoheme, hematoheme dimethyl ester, dicysteinyl hematoheme, and heme undecapeptide, conversion of hematoheme to hematobilirubin requires the presence of: NADPH, NADPH-cytochrome c reductase, biliverdin reductase and O2 | Rattus norvegicus | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
| 1.14.14.18 | heme + electron donor + O2 | intact cytochrome c is not oxidized | Rattus norvegicus | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
| 1.14.14.18 | heme + electron donor + O2 | electron donor NADPH | Rattus norvegicus | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.14.14.18 | 50 | - |
complete loss of activity | Rattus norvegicus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.14.18 | 7.4 | - |
- |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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