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Literature summary extracted from
- Purification and characterization of heme oxygenase from chick liver. Comparison of the avian and mammalian enzymes (1990), Eur. J. Biochem., 189, 155-160.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.18 | Hg2+ | - |
Gallus gallus |  |
| 1.14.14.18 | Porphyrins | metalloporphyrins, decreasing order of inhibition potency: Sn-mesoporphyrin, Sn-protoporphyrin, Zn-protoporphyrin, Mn-protoporphyrin, Co-protoporphyrin | Gallus gallus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.14.18 | 0.0038 | - |
heme | in the absence of bovine serum albumin | Gallus gallus | |
| 1.14.14.18 | 0.005 | - |
heme | in the presence of bovine serum albumin | Gallus gallus | |
| 1.14.14.18 | 0.0061 | - |
NADPH | - |
Gallus gallus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.14.18 | microsome | - |
Gallus gallus | - |
- |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.14.14.18 | 33000 | - |
x * 33000, SDS-PAGE | Gallus gallus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.14.18 | Gallus gallus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.14.14.18 | DEAE-Sephacel, carboxymethyl-cellulose, hydroxyapatite, Superose 6/12 | Gallus gallus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.14.18 | liver | - |
Gallus gallus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.14.14.18 | 0.433 | - |
- |
Gallus gallus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.18 | heme + 2 NADPH + 2 H+ + 2 O2 | - |
Gallus gallus | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? | |
| 1.14.14.18 | heme + electron donor + O2 | electron donor NADPH | Gallus gallus | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.14.14.18 | ? | x * 33000, SDS-PAGE | Gallus gallus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.14.14.18 | 37 | - |
assay at | Gallus gallus |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.14.18 | 0.32 | - |
heme | - |
Gallus gallus | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.14.18 | 7.2 | 7.5 | - |
Gallus gallus |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.14.18 | 6.5 | 7.9 | pH 6.5: 63% activity, pH 7.9: 50% activity | Gallus gallus |
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Release 2023.1 (January 2023)
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