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Literature summary extracted from

  • Lindqvist, A.; Andersson, S.
    Biochemical properties of purified recombinant human beta-carotene 15,15'-monooxygenase (2002), J. Biol. Chem., 277, 23942-23948.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.13.11.63 1-S-octyl-beta-D-thioglucopyranoside detergent required, maximal activity at 1% w/v Homo sapiens
1.13.11.63 octyl beta-glucoside detergent required Homo sapiens
1.13.11.63 SDS detergent required, low activation Homo sapiens
1.13.11.63 sodium cholate detergent required Homo sapiens
1.13.11.63 Triton X-100 detergent required Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.13.11.63 expression by an baculovirus/Spodoptera frugiperda 9 insect cell system Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.63 2,2'-dipyridyl
-
 Homo sapiens
1.13.11.63 PCMB
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.13.11.63 0.0071
-
 beta-carotene
-
 Homo sapiens
1.13.11.63 0.03
-
 beta-cryptoxanthin
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.13.11.63 230000
-
 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.63 beta-carotene + O2 Homo sapiens the enzyme catalyzes the first step in the synthesis of vitamin A from dietary carotenoids. May also play a role in peripheral vitamin A synthesis from plasma-borne provitamin A carotenoids retinal
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.63 Homo sapiens Q9HAY6
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.13.11.63
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.63 intestine high levels of BCO mRNA, highest level in jejunum Homo sapiens
-
1.13.11.63 kidney high levels of BCO mRNA Homo sapiens
-
1.13.11.63 liver high levels of BCO mRNA Homo sapiens
-
1.13.11.63 ovary low levels of BCO mRNA Homo sapiens
-
1.13.11.63 prostate gland low levels of BCO mRNA Homo sapiens
-
1.13.11.63 skeletal muscle low levels of BCO mRNA Homo sapiens
-
1.13.11.63 testis low levels of BCO mRNA Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.63 beta-carotene + O2 the enzyme catalyzes the first step in the synthesis of vitamin A from dietary carotenoids. May also play a role in peripheral vitamin A synthesis from plasma-borne provitamin A carotenoids Homo sapiens retinal
-
 ?
1.13.11.63 beta-cryptoxanthin + O2
-
 Homo sapiens ?
-
 ?
1.13.11.63 beta-cryptoxanthin + O2
-
 Homo sapiens all-trans-retinal + ?
-
 r

Subunits

EC Number Subunits Comment Organism
1.13.11.63 tetramer
-
 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.13.11.63 BCO
-
 Homo sapiens
1.13.11.63 beta-carotene 15,15'-monooxygenase
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.13.11.63 0.011
-
 beta-carotene
-
 Homo sapiens
1.13.11.63 0.668
-
 beta-cryptoxanthin
-
 Homo sapiens