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Literature summary extracted from

  • Satoh, T.; Horie, M.; Watanabe, H.; Tsuchiya, Y.; Kamei, T.
    Enzymic properties of squalene epoxidase from Saccharomyces cerevisiae (1993), Biol. Pharm. Bull., 16, 349-352.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.17 NB-598 0.045 mM, 50% inhibition, partial non-competitive Saccharomyces cerevisiae
1.14.14.17 terbinafine 0.18 mM, 50% inhibition, non-competitive Saccharomyces cerevisiae
1.14.14.17 Triton X-100 0.02%, 50% inhibition Saccharomyces cerevisiae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.14.17 0.0135
-
 squalene
-
 Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.17 microsome
-
 Saccharomyces cerevisiae
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.17 Saccharomyces cerevisiae
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.14.17 0.0000321
-
 activity in microsomal fraction Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.17 squalene + NAD(P)H + O2 specific for NADPH Saccharomyces cerevisiae (S)-squalene-2,3-epoxide + NADP+ + H2O
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.14.17 7.5
-
-
 Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.17 additional information FAD is not essential for activity, 76.2% activity in the absence of FAD Saccharomyces cerevisiae

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.14.17 0.000075
-
 terbinafine
-
 Saccharomyces cerevisiae
1.14.14.17 0.0087
-
 NB-598
-
 Saccharomyces cerevisiae