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Literature summary extracted from
- In vitro assay of squalene epoxidase of Saccharomyces cerevisiae (1987), Biochem. Biophys. Res. Commun., 147, 556-564.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.17 | H2O2 | inhibition above 2 mM | Saccharomyces cerevisiae |  |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.14.17 | 0.0043 | - |
O2 | - |
Saccharomyces cerevisiae | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.14.17 | Saccharomyces cerevisiae | - |
enzyme is depressed in anaerobically grown cells | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.14.14.17 | 0.0001 | - |
activity in cell-free extract | Saccharomyces cerevisiae |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 1.14.14.17 | -25°C, overnight, 2fold decrease of activity in crude extracts | Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.17 | squalene + NAD(P)H + O2 | NADPH is preferred | Saccharomyces cerevisiae | (S)-squalene-2,3-epoxide + NADP+ + H2O | - |
? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.14.14.17 | 30 | 37 | activity in crude extract | Saccharomyces cerevisiae |
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Release 2023.1 (January 2023)
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