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Literature summary extracted from

  • Holdom, M.D.; Lechenne, B.; Hay, R.J.; Hamilton, A.J.; Monod, M.
    Production and characterization of recombinant Aspergillus fumigatus Cu,Zn superoxide dismutase and its recognition by immune human sera (2000), J. Clin. Microbiol., 38, 558-562.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
1.15.1.1 medicine recombinant protein is useful as serodiagnostic marker for identification of Aspergillus fumigatus infections, crossreactive antibodies Aspergillus fumigatus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.15.1.1 expression in Pichia pastoris, DNA and amino acid sequence determination and comparison Aspergillus fumigatus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.15.1.1 diethyldithiocarbamate complete inhibition, Cu,Zn-SOD Aspergillus fumigatus
1.15.1.1 EDTA no inhibition Aspergillus fumigatus
1.15.1.1 H2O2 complete inhibition; Cu,Zn-SOD Aspergillus fumigatus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.15.1.1 Cu2+
-
 Aspergillus fumigatus
1.15.1.1 Zn2+
-
 Aspergillus fumigatus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.15.1.1 19500
-
 amino acid sequence determination, SDS-PAGE Aspergillus fumigatus
1.15.1.1 19500
-
 native Cu,Zn-SOD Aspergillus fumigatus
1.15.1.1 21500
-
 SDS-PAGE Aspergillus fumigatus
1.15.1.1 21500
-
 amino acid sequence determination Aspergillus fumigatus
1.15.1.1 21500
-
 recombinant Cu,Zn-SOD Aspergillus fumigatus

Organism

EC Number Organism UniProt Comment Textmining
1.15.1.1 Aspergillus fumigatus Q9Y8D9 Cu,Zn-SOD
-
1.15.1.1 Aspergillus fumigatus Af293 Q9Y8D9 Cu,Zn-SOD
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.15.1.1 Cu,Zn-SOD, native and recombinant from Pichia pastoris Aspergillus fumigatus

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.15.1.1 O2- + H+
-
 Aspergillus fumigatus O2 + H2O2
-
 ?
1.15.1.1 O2- + H+
-
 Aspergillus fumigatus Af293 O2 + H2O2
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.15.1.1 37
-
 native and recombinant Cu,Zn-SOD Aspergillus fumigatus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.15.1.1 7 11 native and recombinant Cu,Zn-SOD, activity is pH-independent Aspergillus fumigatus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.15.1.1 7 11 native and recombinant Cu,Zn-SOD, activity is pH-independent Aspergillus fumigatus