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Literature summary extracted from

  • Le Trant, N.; Meshnick, S.R.; Kitchener, K.; Eaton, J.W.; Cerami, A.
    Iron-containing superoxide dismutase from Crithidia fasciculata. Purification, characterization, and similarity to Leishmanial and trypanosomal enzymes (1983), J. Biol. Chem., 258, 125-130.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.15.1.1 CN- no inhibition Crithidia fasciculata
1.15.1.1 CN- no inhibition Leishmania tropica
1.15.1.1 CN- no inhibition Trypanosoma brucei
1.15.1.1 CN- no inhibition Trypanosoma cruzi
1.15.1.1 H2O2
-
 Crithidia fasciculata
1.15.1.1 H2O2
-
 Leishmania tropica
1.15.1.1 H2O2
-
 Trypanosoma brucei
1.15.1.1 H2O2
-
 Trypanosoma cruzi
1.15.1.1 N3-
-
 Crithidia fasciculata
1.15.1.1 N3-
-
 Leishmania tropica
1.15.1.1 N3-
-
 Trypanosoma brucei
1.15.1.1 N3-
-
 Trypanosoma cruzi

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.15.1.1 cytoplasm
-
 Trypanosoma brucei 5737
-
1.15.1.1 cytoplasm
-
 Trypanosoma cruzi 5737
-
1.15.1.1 cytoplasm
-
 Leishmania tropica 5737
-
1.15.1.1 cytoplasm Fe-SOD Crithidia fasciculata 5737
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.15.1.1 Iron 2.7-2.8 mol per mol of enzyme Trypanosoma brucei
1.15.1.1 Iron 2.7-2.8 mol per mol of enzyme Crithidia fasciculata
1.15.1.1 Iron 2.7-2.8 mol per mol of enzyme Trypanosoma cruzi
1.15.1.1 Iron 2.7-2.8 mol per mol of enzyme Leishmania tropica

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.15.1.1 23000
-
 2 * 23000, gel filtration, isoenzyme 2 and 3 Crithidia fasciculata
1.15.1.1 39000
-
 isoenzyme 3, gel filtration Crithidia fasciculata
1.15.1.1 43000
-
 isoenzyme 2, gel filtration Crithidia fasciculata

Organism

EC Number Organism UniProt Comment Textmining
1.15.1.1 Crithidia fasciculata
-
 Fe-SOD
-
1.15.1.1 Crithidia fasciculata
-
 3 isozymes
-
1.15.1.1 Crithidia fasciculata Fe-SOD
-
 Fe-SOD
-
1.15.1.1 Leishmania tropica
-
-
-
1.15.1.1 Trypanosoma brucei
-
-
-
1.15.1.1 Trypanosoma cruzi
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.15.1.1 3 isoenzymes: 1, 2 and 3 Crithidia fasciculata

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.15.1.1 O2- + H+
-
 Trypanosoma brucei O2 + H2O2
-
 ?
1.15.1.1 O2- + H+
-
 Crithidia fasciculata O2 + H2O2
-
 ?
1.15.1.1 O2- + H+
-
 Trypanosoma cruzi O2 + H2O2
-
 ?
1.15.1.1 O2- + H+
-
 Leishmania tropica O2 + H2O2
-
 ?
1.15.1.1 O2- + H+
-
 Crithidia fasciculata Fe-SOD O2 + H2O2
-
 ?

Subunits

EC Number Subunits Comment Organism
1.15.1.1 dimer 2 * 23000, gel filtration, isoenzyme 2 and 3 Crithidia fasciculata