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Literature summary extracted from

  • Miller, S.M.; Ballou, D.P.; Massey, V.; Williams, C.H.; Walsh, C.T.
    Two-electron reduced mercuric reductase binds Hg(II) to the active site dithiol but does not catalyze Hg(II) reduction (1986), J. Biol. Chem., 261, 8081-8084.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.16.1.1 thiol exogenous thiols are required for catalytic reduction of Hg(II) to Hg2+, due to prevention or reversal of formation of an abortive complex of Hg(II) with the thiol/thiolate pair of two-electron reduced enzyme Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
1.16.1.1 Escherichia coli
-
 W3110 lacIq containing the plasmid pPSO1
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.16.1.1 Hg2+ + NADPH
-
 Escherichia coli Hg + NADP+ + H+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.16.1.1 NADPH
-
 Escherichia coli