Literature summary extracted from

Cory, J.G.; Cory, A.H.; Downes, D.L.
Differential substrate properties of mammalian ribonucleotide reductase (1995), Purine and pyrimidine metabolism in man VIII ed. (Sahota A. and Taylor M. ed.), , 631-635.

No PubMed abstract available

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.17.4.1	monoclonal antibody raised against yeast tubulin	CDP reductase activity is inhibited to a greater extent than ADP, UDP or GDP reductase activity, antibody recognizes a specific sequence in the C-terminal region on the R2 subunit	Mus musculus
1.17.4.1	NSFTLDADF	inhibition of CDP reductase activity, peptide corresponds to the C-terminal region of the R2 subunit and competes with binding of R2 to the R1 subunit	Mus musculus

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.17.4.1	Mus musculus	-	Ehrlich ascites tumor cells	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.17.4.1	ribonucleoside diphosphate + reduced thioredoxin	-	Mus musculus	2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O	-	ir

Subunits

EC Number	Subunits	Comment	Organism
1.17.4.1	More	large subunit R1 contains binding sites for substrates and allosteric effectors, smaller subunit R2 contains non-heme iron and a tyrosyl free-radical	Mus musculus

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Release 2023.1 (January 2023)