BRENDA - Enzyme Database

Ribonucleotide reductase from regenerating rat liver. II. Substrate phosphorylation level and effect of deoxyadenosine triphosphate

Larsson, A.; Biochim. Biophys. Acta 324, 447-451 (1973)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
1.17.4.1
ATP
-
Rattus norvegicus
1.17.4.1
dATP
0.005 mM, stimulation of CDP reduction in absence of ATP, inhibition in presence of ATP
Rattus norvegicus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.17.4.1
dATP
0.05 mM, 50% inhibition of CDP reduction in presence of optimum ATP concentration i.e. 6 mM, stimulation in absence of ATP; inhibition of CDP reduction
Rattus norvegicus
1.17.4.1
Fe2+
no effect of iron salts
Rattus norvegicus
1.17.4.1
Hydroxyurea
-
Rattus norvegicus
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1.17.4.1
0.01
-
CDP
-
Rattus norvegicus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.17.4.1
Rattus norvegicus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.17.4.1
liver
regenerating liver
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437969
Rattus norvegicus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437969
Rattus norvegicus
ir
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
1.17.4.1
ATP
-
Rattus norvegicus
1.17.4.1
dATP
0.005 mM, stimulation of CDP reduction in absence of ATP, inhibition in presence of ATP
Rattus norvegicus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.17.4.1
dATP
0.05 mM, 50% inhibition of CDP reduction in presence of optimum ATP concentration i.e. 6 mM, stimulation in absence of ATP; inhibition of CDP reduction
Rattus norvegicus
1.17.4.1
Fe2+
no effect of iron salts
Rattus norvegicus
1.17.4.1
Hydroxyurea
-
Rattus norvegicus
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1.17.4.1
0.01
-
CDP
-
Rattus norvegicus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.17.4.1
liver
regenerating liver
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437969
Rattus norvegicus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437969
Rattus norvegicus
ir