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Literature summary extracted from

  • Elford, H.L.
    Functional regulation of mammalian ribonucleotide reductase (1972), Adv. Enzyme Regul., 10, 19-38.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.17.4.1 cytoplasm enzyme from Novikoff hepatoma tumor cells is associated with a smooth membrane component of the cytoplasm Rattus norvegicus 5737
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.4.1 ribonucleoside diphosphate + reduced thioredoxin Rattus norvegicus critical and rate-controlling step in pathway leading to DNA synthesis and cell replication 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
?
1.17.4.1 ribonucleoside diphosphate + reduced thioredoxin Rattus norvegicus thioredoxin is the physiological reductant 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
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?

Organism

EC Number Organism UniProt Comment Textmining
1.17.4.1 Rattus norvegicus
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Morris hepatoma cells
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1.17.4.1 Rattus norvegicus
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Novikoff hepatoma cells
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Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.17.4.1 additional information
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strong increase of specific activity during growth of Novikoff hepatoma cells Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.4.1 ribonucleoside diphosphate + reduced thioredoxin
-
Rattus norvegicus 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
ir
1.17.4.1 ribonucleoside diphosphate + reduced thioredoxin critical and rate-controlling step in pathway leading to DNA synthesis and cell replication Rattus norvegicus 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
?
1.17.4.1 ribonucleoside diphosphate + reduced thioredoxin thioredoxin is the physiological reductant Rattus norvegicus 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
?