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Literature summary extracted from
- Ribonucleotide reductase of rabbit bone marrow. I. Purification, properties, and separation into two protein fractions (1972), J. Biol. Chem., 247, 3336-3340.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.17.4.1 | ATP | stimulation of CDP reduction | Oryctolagus cuniculus |  |
| 1.17.4.1 | Dithiols | required for in vitro reduction | Oryctolagus cuniculus |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.17.4.1 | Iron | Fe2+ stimulates | Oryctolagus cuniculus | |
| 1.17.4.1 | Mg2+ | absolutely required | Oryctolagus cuniculus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.17.4.1 | Oryctolagus cuniculus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.17.4.1 | ammonium sulfate, Sephadex G-200, partially purified | Oryctolagus cuniculus |
| 1.17.4.1 | partial | Oryctolagus cuniculus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.17.4.1 | bone marrow | - |
Oryctolagus cuniculus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.17.4.1 | 0.00028 | - |
partially purified enzyme | Oryctolagus cuniculus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.17.4.1 | ribonucleoside diphosphate + reduced thioredoxin | - |
Oryctolagus cuniculus | 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O | - |
ir | |
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