BRENDA - Enzyme Database

Regulation of ribonucleotide reductase

Holmgren, A.; Curr. Top. Cell. Regul. 19, 47-76 (1981)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
1.17.4.1
ATP
stimulation of CDP reduction; stimulation of UDP reduction
Bos taurus
1.17.4.1
ATP
-
Enterobacteria phage T2
1.17.4.1
ATP
-
Enterobacteria phage T6
1.17.4.1
ATP
stimulation of CDP reduction; stimulation of UDP reduction
Escherichia virus T4
1.17.4.1
ATP
-
Escherichia virus T5
1.17.4.1
ATP
stimulation of CDP reduction; stimulation of UDP reduction
Homo sapiens
1.17.4.1
ATP
stimulation of CDP reduction; stimulation of UDP reduction
Oryctolagus cuniculus
1.17.4.1
ATP
stimulation of CDP reduction
Rattus norvegicus
1.17.4.1
ATP
stimulation of CDP reduction; stimulation of UDP reduction
Escherichia coli
1.17.4.1
dGTP
stimulation of ADP reduction
Bos taurus
1.17.4.1
dGTP
-
Enterobacteria phage T2
1.17.4.1
dGTP
-
Enterobacteria phage T6
1.17.4.1
dGTP
stimulation of ADP reduction
Escherichia coli
1.17.4.1
dGTP
-
Escherichia virus T4
1.17.4.1
dGTP
-
Escherichia virus T5
1.17.4.1
dGTP
stimulation of ADP reduction
Homo sapiens
1.17.4.1
dGTP
stimulation of ADP reduction
Oryctolagus cuniculus
1.17.4.1
dGTP
-
Rattus norvegicus
1.17.4.1
dTTP
stimulation of GDP reduction
Bos taurus
1.17.4.1
dTTP
-
Enterobacteria phage T2
1.17.4.1
dTTP
-
Enterobacteria phage T6
1.17.4.1
dTTP
stimulation of GDP reduction
Escherichia coli
1.17.4.1
dTTP
stimulation of GDP reduction
Escherichia virus T4
1.17.4.1
dTTP
-
Escherichia virus T5
1.17.4.1
dTTP
stimulation of GDP reduction
Homo sapiens
1.17.4.1
dTTP
stimulation of GDP reduction
Oryctolagus cuniculus
1.17.4.1
dTTP
stimulation of GDP reduction
Rattus norvegicus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.17.4.1
3,5-diamino-1H-1,2,4-triazole
0.001 mM, 50% inhibition of CDP and UDP reduction, 0.05 mM, 50% inhibition of ADP reduction
Bos taurus
1.17.4.1
3,5-diamino-1H-1,2,4-triazole
-
Homo sapiens
1.17.4.1
dATP
0.005 mM, 50% inhibition of CDP and UDP reduction, 0.005 mM, 50% inhibition of GDP and ADP reduction; inhibition of ADP reduction; inhibition of CDP reduction; inhibition of GDP reduction
Bos taurus
1.17.4.1
dATP
inhibition of ADP reduction
Enterobacteria phage T2
1.17.4.1
dATP
inhibition of ADP reduction
Enterobacteria phage T6
1.17.4.1
dATP
inhibition of ADP reduction; inhibition of CDP reduction; inhibition of GDP reduction
Escherichia coli
1.17.4.1
dATP
inhibition of ADP reduction; inhibition of CDP reduction; inhibition of GDP reduction
Escherichia virus T4
1.17.4.1
dATP
inhibition of ADP reduction
Escherichia virus T5
1.17.4.1
dATP
inhibition of ADP reduction; inhibition of CDP reduction; inhibition of GDP reduction
Homo sapiens
1.17.4.1
dATP
inhibition of ADP reduction; inhibition of CDP reduction; inhibition of GDP reduction
Oryctolagus cuniculus
1.17.4.1
dATP
inhibition of ADP reduction; inhibition of CDP reduction; inhibition of GDP reduction
Rattus norvegicus
1.17.4.1
dGTP
0.05 mM, 50% inhibition of GDP reduction; 0.1 mM, 50% inhibition of CDP and UDP reduction; inhibition of UDP reduction
Bos taurus
1.17.4.1
dGTP
-
Enterobacteria phage T2
1.17.4.1
dGTP
-
Enterobacteria phage T6
1.17.4.1
dGTP
-
Escherichia coli
1.17.4.1
dGTP
-
Escherichia virus T4
1.17.4.1
dGTP
-
Escherichia virus T5
1.17.4.1
dGTP
-
Homo sapiens
1.17.4.1
dGTP
-
Oryctolagus cuniculus
1.17.4.1
dGTP
inhibition of UDP reduction
Rattus norvegicus
1.17.4.1
dTTP
inhibition of UDP reduction
Bos taurus
1.17.4.1
dTTP
-
Enterobacteria phage T2
1.17.4.1
dTTP
-
Enterobacteria phage T6
1.17.4.1
dTTP
inhibition of ADP reduction
Escherichia coli
1.17.4.1
dTTP
-
Escherichia virus T4
1.17.4.1
dTTP
-
Escherichia virus T5
1.17.4.1
dTTP
-
Homo sapiens
1.17.4.1
dTTP
-
Oryctolagus cuniculus
1.17.4.1
dTTP
inhibition of UDP reduction
Rattus norvegicus
1.17.4.1
EDTA
-
Homo sapiens
1.17.4.1
EDTA
-
Rattus norvegicus
1.17.4.1
EDTA
-
Bos taurus
1.17.4.1
EDTA
-
Escherichia coli
1.17.4.1
Hydroxyurea
-
Bos taurus
1.17.4.1
Hydroxyurea
-
Escherichia virus T4
1.17.4.1
Hydroxyurea
-
Escherichia virus T5
1.17.4.1
Hydroxyurea
-
Rattus norvegicus
1.17.4.1
Hydroxyurea
-
Escherichia coli
1.17.4.1
Hydroxyurea
-
Oryctolagus cuniculus
1.17.4.1
Hydroxyurea
-
Homo sapiens
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.17.4.1
Bos taurus
-
-
-
1.17.4.1
Enterobacteria phage T2
-
-
-
1.17.4.1
Enterobacteria phage T6
-
-
-
1.17.4.1
Escherichia coli
-
-
-
1.17.4.1
Escherichia virus T4
-
enzyme induced in Escherichia coli by infection with bacteriophage T4
-
1.17.4.1
Escherichia virus T5
-
may use triphosphates as substrates
-
1.17.4.1
Homo sapiens
-
-
-
1.17.4.1
Oryctolagus cuniculus
-
-
-
1.17.4.1
Rattus norvegicus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.17.4.1
Novikoff ascites tumor cell
-
Rattus norvegicus
-
1.17.4.1
thymus
-
Bos taurus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437937
Escherichia coli
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437937
Escherichia coli
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437937
Homo sapiens
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437937
Homo sapiens
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437937
Rattus norvegicus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437937
Rattus norvegicus
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437937
Bos taurus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437937
Bos taurus
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437937
Oryctolagus cuniculus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437937
Oryctolagus cuniculus
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437937
Escherichia virus T4
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437937
Escherichia virus T4
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437937
Enterobacteria phage T2
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437937
Enterobacteria phage T2
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437937
Enterobacteria phage T6
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437937
Enterobacteria phage T6
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437937
Escherichia virus T5
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437937
Escherichia virus T5
ir
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
1.17.4.1
ATP
stimulation of CDP reduction; stimulation of UDP reduction
Bos taurus
1.17.4.1
ATP
-
Enterobacteria phage T2
1.17.4.1
ATP
-
Enterobacteria phage T6
1.17.4.1
ATP
stimulation of CDP reduction; stimulation of UDP reduction
Escherichia virus T4
1.17.4.1
ATP
-
Escherichia virus T5
1.17.4.1
ATP
stimulation of CDP reduction; stimulation of UDP reduction
Homo sapiens
1.17.4.1
ATP
stimulation of CDP reduction; stimulation of UDP reduction
Oryctolagus cuniculus
1.17.4.1
ATP
stimulation of CDP reduction
Rattus norvegicus
1.17.4.1
ATP
stimulation of CDP reduction; stimulation of UDP reduction
Escherichia coli
1.17.4.1
dGTP
stimulation of ADP reduction
Bos taurus
1.17.4.1
dGTP
-
Enterobacteria phage T2
1.17.4.1
dGTP
-
Enterobacteria phage T6
1.17.4.1
dGTP
stimulation of ADP reduction
Escherichia coli
1.17.4.1
dGTP
-
Escherichia virus T4
1.17.4.1
dGTP
-
Escherichia virus T5
1.17.4.1
dGTP
stimulation of ADP reduction
Homo sapiens
1.17.4.1
dGTP
stimulation of ADP reduction
Oryctolagus cuniculus
1.17.4.1
dGTP
-
Rattus norvegicus
1.17.4.1
dTTP
stimulation of GDP reduction
Bos taurus
1.17.4.1
dTTP
-
Enterobacteria phage T2
1.17.4.1
dTTP
-
Enterobacteria phage T6
1.17.4.1
dTTP
stimulation of GDP reduction
Escherichia coli
1.17.4.1
dTTP
stimulation of GDP reduction
Escherichia virus T4
1.17.4.1
dTTP
-
Escherichia virus T5
1.17.4.1
dTTP
stimulation of GDP reduction
Homo sapiens
1.17.4.1
dTTP
stimulation of GDP reduction
Oryctolagus cuniculus
1.17.4.1
dTTP
stimulation of GDP reduction
Rattus norvegicus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.17.4.1
3,5-diamino-1H-1,2,4-triazole
0.001 mM, 50% inhibition of CDP and UDP reduction, 0.05 mM, 50% inhibition of ADP reduction
Bos taurus
1.17.4.1
3,5-diamino-1H-1,2,4-triazole
-
Homo sapiens
1.17.4.1
dATP
0.005 mM, 50% inhibition of CDP and UDP reduction, 0.005 mM, 50% inhibition of GDP and ADP reduction; inhibition of ADP reduction; inhibition of CDP reduction; inhibition of GDP reduction
Bos taurus
1.17.4.1
dATP
inhibition of ADP reduction
Enterobacteria phage T2
1.17.4.1
dATP
inhibition of ADP reduction
Enterobacteria phage T6
1.17.4.1
dATP
inhibition of ADP reduction; inhibition of CDP reduction; inhibition of GDP reduction
Escherichia coli
1.17.4.1
dATP
inhibition of ADP reduction; inhibition of CDP reduction; inhibition of GDP reduction
Escherichia virus T4
1.17.4.1
dATP
inhibition of ADP reduction
Escherichia virus T5
1.17.4.1
dATP
inhibition of ADP reduction; inhibition of CDP reduction; inhibition of GDP reduction
Homo sapiens
1.17.4.1
dATP
inhibition of ADP reduction; inhibition of CDP reduction; inhibition of GDP reduction
Oryctolagus cuniculus
1.17.4.1
dATP
inhibition of ADP reduction; inhibition of CDP reduction; inhibition of GDP reduction
Rattus norvegicus
1.17.4.1
dGTP
0.05 mM, 50% inhibition of GDP reduction; 0.1 mM, 50% inhibition of CDP and UDP reduction; inhibition of UDP reduction
Bos taurus
1.17.4.1
dGTP
-
Enterobacteria phage T2
1.17.4.1
dGTP
-
Enterobacteria phage T6
1.17.4.1
dGTP
-
Escherichia coli
1.17.4.1
dGTP
-
Escherichia virus T4
1.17.4.1
dGTP
-
Escherichia virus T5
1.17.4.1
dGTP
-
Homo sapiens
1.17.4.1
dGTP
-
Oryctolagus cuniculus
1.17.4.1
dGTP
inhibition of UDP reduction
Rattus norvegicus
1.17.4.1
dTTP
inhibition of UDP reduction
Bos taurus
1.17.4.1
dTTP
-
Enterobacteria phage T2
1.17.4.1
dTTP
-
Enterobacteria phage T6
1.17.4.1
dTTP
inhibition of ADP reduction
Escherichia coli
1.17.4.1
dTTP
-
Escherichia virus T4
1.17.4.1
dTTP
-
Escherichia virus T5
1.17.4.1
dTTP
-
Homo sapiens
1.17.4.1
dTTP
-
Oryctolagus cuniculus
1.17.4.1
dTTP
inhibition of UDP reduction
Rattus norvegicus
1.17.4.1
EDTA
-
Homo sapiens
1.17.4.1
EDTA
-
Rattus norvegicus
1.17.4.1
EDTA
-
Bos taurus
1.17.4.1
EDTA
-
Escherichia coli
1.17.4.1
Hydroxyurea
-
Bos taurus
1.17.4.1
Hydroxyurea
-
Escherichia virus T4
1.17.4.1
Hydroxyurea
-
Escherichia virus T5
1.17.4.1
Hydroxyurea
-
Rattus norvegicus
1.17.4.1
Hydroxyurea
-
Escherichia coli
1.17.4.1
Hydroxyurea
-
Oryctolagus cuniculus
1.17.4.1
Hydroxyurea
-
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.17.4.1
Novikoff ascites tumor cell
-
Rattus norvegicus
-
1.17.4.1
thymus
-
Bos taurus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437937
Escherichia coli
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437937
Escherichia coli
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437937
Homo sapiens
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437937
Homo sapiens
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437937
Rattus norvegicus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437937
Rattus norvegicus
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437937
Bos taurus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437937
Bos taurus
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437937
Oryctolagus cuniculus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437937
Oryctolagus cuniculus
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437937
Escherichia virus T4
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437937
Escherichia virus T4
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437937
Enterobacteria phage T2
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437937
Enterobacteria phage T2
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437937
Enterobacteria phage T6
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437937
Enterobacteria phage T6
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437937
Escherichia virus T5
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437937
Escherichia virus T5
ir