Any feedback?
Literature summary extracted from
- Regulation of ribonucleotide reductase (1981), Curr. Top. Cell. Regul., 19, 47-76.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.17.4.1 | ATP | - |
Escherichia phage T2 |  |
| 1.17.4.1 | ATP | - |
Enterobacteria phage T6 | |
| 1.17.4.1 | ATP | - |
Tequintavirus T5 | |
| 1.17.4.1 | ATP | stimulation of UDP reduction | Escherichia coli | |
| 1.17.4.1 | ATP | stimulation of UDP reduction | Homo sapiens | |
| 1.17.4.1 | ATP | stimulation of UDP reduction | Bos taurus | |
| 1.17.4.1 | ATP | stimulation of UDP reduction | Oryctolagus cuniculus | |
| 1.17.4.1 | ATP | stimulation of UDP reduction | Tequatrovirus T4 | |
| 1.17.4.1 | ATP | stimulation of CDP reduction | Escherichia coli | |
| 1.17.4.1 | ATP | stimulation of CDP reduction | Homo sapiens | |
| 1.17.4.1 | ATP | stimulation of CDP reduction | Rattus norvegicus | |
| 1.17.4.1 | ATP | stimulation of CDP reduction | Bos taurus | |
| 1.17.4.1 | ATP | stimulation of CDP reduction | Oryctolagus cuniculus | |
| 1.17.4.1 | ATP | stimulation of CDP reduction | Tequatrovirus T4 | |
| 1.17.4.1 | dGTP | - |
Rattus norvegicus | |
| 1.17.4.1 | dGTP | - |
Tequatrovirus T4 | |
| 1.17.4.1 | dGTP | - |
Escherichia phage T2 | |
| 1.17.4.1 | dGTP | - |
Enterobacteria phage T6 | |
| 1.17.4.1 | dGTP | - |
Tequintavirus T5 | |
| 1.17.4.1 | dGTP | stimulation of ADP reduction | Escherichia coli | |
| 1.17.4.1 | dGTP | stimulation of ADP reduction | Homo sapiens | |
| 1.17.4.1 | dGTP | stimulation of ADP reduction | Bos taurus | |
| 1.17.4.1 | dGTP | stimulation of ADP reduction | Oryctolagus cuniculus | |
| 1.17.4.1 | dTTP | - |
Escherichia phage T2 | |
| 1.17.4.1 | dTTP | - |
Enterobacteria phage T6 | |
| 1.17.4.1 | dTTP | - |
Tequintavirus T5 | |
| 1.17.4.1 | dTTP | stimulation of GDP reduction | Escherichia coli | |
| 1.17.4.1 | dTTP | stimulation of GDP reduction | Homo sapiens | |
| 1.17.4.1 | dTTP | stimulation of GDP reduction | Rattus norvegicus | |
| 1.17.4.1 | dTTP | stimulation of GDP reduction | Bos taurus | |
| 1.17.4.1 | dTTP | stimulation of GDP reduction | Oryctolagus cuniculus | |
| 1.17.4.1 | dTTP | stimulation of GDP reduction | Tequatrovirus T4 | |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.17.4.1 | 3,5-diamino-1H-1,2,4-triazole | 0.001 mM, 50% inhibition of CDP and UDP reduction, 0.05 mM, 50% inhibition of ADP reduction | Bos taurus | |
| 1.17.4.1 | 3,5-diamino-1H-1,2,4-triazole | - |
Homo sapiens | |
| 1.17.4.1 | dATP | 0.005 mM, 50% inhibition of CDP and UDP reduction, 0.005 mM, 50% inhibition of GDP and ADP reduction; inhibition of ADP reduction; inhibition of CDP reduction; inhibition of GDP reduction | Bos taurus | |
| 1.17.4.1 | dATP | inhibition of ADP reduction | Enterobacteria phage T6 | |
| 1.17.4.1 | dATP | inhibition of ADP reduction; inhibition of CDP reduction; inhibition of GDP reduction | Escherichia coli | |
| 1.17.4.1 | dATP | inhibition of ADP reduction | Escherichia phage T2 | |
| 1.17.4.1 | dATP | inhibition of ADP reduction; inhibition of CDP reduction; inhibition of GDP reduction | Homo sapiens | |
| 1.17.4.1 | dATP | inhibition of ADP reduction; inhibition of CDP reduction; inhibition of GDP reduction | Oryctolagus cuniculus | |
| 1.17.4.1 | dATP | inhibition of ADP reduction; inhibition of CDP reduction; inhibition of GDP reduction | Rattus norvegicus | |
| 1.17.4.1 | dATP | inhibition of ADP reduction; inhibition of CDP reduction; inhibition of GDP reduction | Tequatrovirus T4 | |
| 1.17.4.1 | dATP | inhibition of ADP reduction | Tequintavirus T5 | |
| 1.17.4.1 | dGTP | 0.05 mM, 50% inhibition of GDP reduction; 0.1 mM, 50% inhibition of CDP and UDP reduction; inhibition of UDP reduction | Bos taurus | |
| 1.17.4.1 | dGTP | - |
Enterobacteria phage T6 | |
| 1.17.4.1 | dGTP | - |
Escherichia coli | |
| 1.17.4.1 | dGTP | - |
Escherichia phage T2 | |
| 1.17.4.1 | dGTP | - |
Homo sapiens | |
| 1.17.4.1 | dGTP | - |
Oryctolagus cuniculus | |
| 1.17.4.1 | dGTP | inhibition of UDP reduction | Rattus norvegicus | |
| 1.17.4.1 | dGTP | - |
Tequatrovirus T4 | |
| 1.17.4.1 | dGTP | - |
Tequintavirus T5 | |
| 1.17.4.1 | dTTP | inhibition of UDP reduction | Bos taurus | |
| 1.17.4.1 | dTTP | - |
Enterobacteria phage T6 | |
| 1.17.4.1 | dTTP | inhibition of ADP reduction | Escherichia coli | |
| 1.17.4.1 | dTTP | - |
Escherichia phage T2 | |
| 1.17.4.1 | dTTP | - |
Homo sapiens | |
| 1.17.4.1 | dTTP | - |
Oryctolagus cuniculus | |
| 1.17.4.1 | dTTP | inhibition of UDP reduction | Rattus norvegicus | |
| 1.17.4.1 | dTTP | - |
Tequatrovirus T4 | |
| 1.17.4.1 | dTTP | - |
Tequintavirus T5 | |
| 1.17.4.1 | EDTA | - |
Bos taurus | |
| 1.17.4.1 | EDTA | - |
Escherichia coli | |
| 1.17.4.1 | EDTA | - |
Homo sapiens | |
| 1.17.4.1 | EDTA | - |
Rattus norvegicus | |
| 1.17.4.1 | Hydroxyurea | - |
Bos taurus | |
| 1.17.4.1 | Hydroxyurea | - |
Escherichia coli | |
| 1.17.4.1 | Hydroxyurea | - |
Homo sapiens | |
| 1.17.4.1 | Hydroxyurea | - |
Oryctolagus cuniculus | |
| 1.17.4.1 | Hydroxyurea | - |
Rattus norvegicus | |
| 1.17.4.1 | Hydroxyurea | - |
Tequatrovirus T4 | |
| 1.17.4.1 | Hydroxyurea | - |
Tequintavirus T5 | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.17.4.1 | Bos taurus | - |
- |
- |
| 1.17.4.1 | Enterobacteria phage T6 | - |
- |
- |
| 1.17.4.1 | Escherichia coli | - |
- |
- |
| 1.17.4.1 | Escherichia phage T2 | - |
- |
- |
| 1.17.4.1 | Homo sapiens | - |
- |
- |
| 1.17.4.1 | Oryctolagus cuniculus | - |
- |
- |
| 1.17.4.1 | Rattus norvegicus | - |
- |
- |
| 1.17.4.1 | Tequatrovirus T4 | - |
enzyme induced in Escherichia coli by infection with bacteriophage T4 | - |
| 1.17.4.1 | Tequintavirus T5 | - |
may use triphosphates as substrates | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.17.4.1 | Novikoff ascites tumor cell | - |
Rattus norvegicus | - |
| 1.17.4.1 | thymus | - |
Bos taurus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.17.4.1 | ribonucleoside diphosphate + reduced thioredoxin | - |
Escherichia coli | 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O | - |
ir | |
| 1.17.4.1 | ribonucleoside diphosphate + reduced thioredoxin | - |
Homo sapiens | 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O | - |
ir | |
| 1.17.4.1 | ribonucleoside diphosphate + reduced thioredoxin | - |
Rattus norvegicus | 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O | - |
ir | |
| 1.17.4.1 | ribonucleoside diphosphate + reduced thioredoxin | - |
Bos taurus | 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O | - |
ir | |
| 1.17.4.1 | ribonucleoside diphosphate + reduced thioredoxin | - |
Oryctolagus cuniculus | 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O | - |
ir | |
| 1.17.4.1 | ribonucleoside diphosphate + reduced thioredoxin | - |
Tequatrovirus T4 | 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O | - |
ir | |
| 1.17.4.1 | ribonucleoside diphosphate + reduced thioredoxin | - |
Escherichia phage T2 | 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O | - |
ir | |
| 1.17.4.1 | ribonucleoside diphosphate + reduced thioredoxin | - |
Enterobacteria phage T6 | 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O | - |
ir | |
| 1.17.4.1 | ribonucleoside diphosphate + reduced thioredoxin | - |
Tequintavirus T5 | 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O | - |
ir | |
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