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Literature summary extracted from

  • Cory, J.G.; Rey, D.A.; Carter, G.L.; Bacon, P.E.
    Nucleoside 5'-diphosphates as effectors of mammalian ribonucleotide reductase (1985), J. Biol. Chem., 260, 12001-12007.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.17.4.1 adenyl-5'-yl-imidodiphosphate can replace ATP as activator of CDP and UDP reduction Mus musculus
1.17.4.1 ADP
-
 Mus musculus
1.17.4.1 dGDP 40% less effective than dGTP Mus musculus
1.17.4.1 dGTP activation of ADP reduction Mus musculus
1.17.4.1 additional information overview: nucleoside 5'-diphosphates as effectors of mammalian ribonucleotide reductase Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.4.1 dATP inhibition of CDP reduction; inhibition of CDP, UDP, GDP and ADP reduction; noncompetitive inhibition vs. ADP, GDP and CDP Mus musculus
1.17.4.1 dGTP inhibition of GDP reduction Mus musculus
1.17.4.1 dTTP inhibition of ADP- CDP- and UDP reduction Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.17.4.1 additional information model of enzyme regulation by nucleoside 5'-triphosphates Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.17.4.1 Mus musculus
-
 Ehrlich ascites tumor cells
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.4.1 Ehrlich ascites carcinoma cell
-
 Mus musculus
-
1.17.4.1 L-1210 cell
-
 Mus musculus
-
1.17.4.1 L-cell cell line Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.4.1 ribonucleoside diphosphate + reduced thioredoxin
-
 Mus musculus 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
 ir